Optical stimulation of cardiac cells with a polymer-supported silicon nanowire matrix.

Autor:	Parameswaran R; Medical Scientist Training Program, The University of Chicago, Chicago, IL 60637.; The Graduate Program in Biophysical Sciences, The University of Chicago, Chicago, IL 60637., Koehler K; Department of Chemistry, The University of Chicago, Chicago, IL 60637., Rotenberg MY; James Franck Institute, The University of Chicago, Chicago, IL 60637., Burke MJ; Department of Chemistry, The University of Chicago, Chicago, IL 60637., Kim J; Department of Physics, Korea University, 02841 Seoul, Korea.; Korea University (KU)-KIST Graduate School of Converging Science and Technology, Korea University, 02841 Seoul, Korea., Jeong KY; Department of Physics, Korea University, 02841 Seoul, Korea.; Korea University (KU)-KIST Graduate School of Converging Science and Technology, Korea University, 02841 Seoul, Korea., Hissa B; James Franck Institute, The University of Chicago, Chicago, IL 60637.; Department of Physics, The University of Chicago, Chicago, IL 60637.; The Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637., Paul MD; Program in Molecular Biophysics, Johns Hopkins University, Baltimore, MD 21218., Moreno K; Department of Chemistry, The University of Chicago, Chicago, IL 60637., Sarma N; Department of Chemistry, The University of Chicago, Chicago, IL 60637., Hayes T; Department of Chemistry, The University of Chicago, Chicago, IL 60637., Sudzilovsky E; Department of Physics, The University of Chicago, Chicago, IL 60637., Park HG; Department of Physics, Korea University, 02841 Seoul, Korea; hgpark@korea.ac.kr btian@uchicago.edu.; Korea University (KU)-KIST Graduate School of Converging Science and Technology, Korea University, 02841 Seoul, Korea., Tian B; Department of Chemistry, The University of Chicago, Chicago, IL 60637; hgpark@korea.ac.kr btian@uchicago.edu.; James Franck Institute, The University of Chicago, Chicago, IL 60637.; The Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637.
Jazyk:	angličtina
Zdroj:	Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Jan 08; Vol. 116 (2), pp. 413-421. Date of Electronic Publication: 2018 Dec 11.
DOI:	10.1073/pnas.1816428115
Abstrakt:	Electronic pacemakers can treat electrical conduction disorders in hearts; however, they are invasive, bulky, and linked to increased incidence of infection at the tissue-device interface. Thus, researchers have looked to other more biocompatible methods for cardiac pacing or resynchronization, such as femtosecond infrared light pulsing, optogenetics, and polymer-based cardiac patches integrated with metal electrodes. Here we develop a biocompatible nongenetic approach for the optical modulation of cardiac cells and tissues. We demonstrate that a polymer-silicon nanowire composite mesh can be used to convert fast moving, low-radiance optical inputs into stimulatory signals in target cardiac cells. Our method allows for the stimulation of the cultured cardiomyocytes or ex vivo heart to beat at a higher target frequency. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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