Correlation of focal adhesion kinase expression with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma.

Autor: Munguía-Calzada P; Service of Dermatology, Hospital Universitario Central de Asturias, Universidad de Oviedo, Oviedo, Spain., Fernández-Vega I; Service of Pathology, Hospital Universitario Central de Asturias, Universidad de Oviedo, Oviedo, Spain., Martínez-Camblor P; Geisel School of Medicine at Dartmouth, Dartmouth College, Hannover, New Hampshire.; Universidad Autónoma de Chile, Santiago, Chile., Díaz-Coto S; Universidad de Oviedo, Oviedo, Spain., García-Pedrero JM; Department of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias, Instituto Universitario de Oncología del Principado de Asturias, University of Oviedo, Oviedo, Spain.; CIBERONC, Madrid, Spain., Vivanco B; Service of Pathology, Hospital Universitario Central de Asturias, Universidad de Oviedo, Oviedo, Spain., Osuna CG; Service of Dermatology, Hospital Universitario Central de Asturias, Universidad de Oviedo, Oviedo, Spain., Vazquez-Lopez F; Service of Dermatology, Hospital Universitario Central de Asturias, Universidad de Oviedo, Oviedo, Spain., Rodrigo JP; Department of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias, Instituto Universitario de Oncología del Principado de Asturias, University of Oviedo, Oviedo, Spain.; CIBERONC, Madrid, Spain., Santos-Juanes J; Service of Dermatology, Hospital Universitario Central de Asturias, Universidad de Oviedo, Oviedo, Spain.
Jazyk: angličtina
Zdroj: Head & neck [Head Neck] 2019 May; Vol. 41 (5), pp. 1290-1296. Date of Electronic Publication: 2018 Dec 10.
DOI: 10.1002/hed.25556
Abstrakt: Background: Focal adhesion kinase (FAK) and cortactin overexpression is frequently detected in a variety of cancers, and has been associated with poor clinical outcome. However, there are no data in cutaneous squamous cell carcinoma (cSCC).
Objective: To investigate the relationship of FAK and cortactin expression with the clinicopathologic features and the impact on the prognosis of cSCC patients.
Methods: FAK and cortactin expression was analyzed by immunohistochemistry on paraffin-embedded tissue samples from 100 patients with cSCC, and correlated with the clinical data.
Results: FAK overexpression was a significant risk factor for nodal metastasis with crude and adjusted ratios (HRs) of 2.04, (95% CI [1.08-3.86], [P = 0.029]) and 2.23 (95% CI [1.01-4.91], [P = 0.047]), respectively. Cortactin expression was not a significant risk factor for nodal metastasis.
Conclusion: These findings demonstrate that FAK overexpression is an independent predictor of nodal metastasis that might be helpful for risk stratification and management of patients with cSCC.
(© 2018 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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