Synthesis of methotrexate-loaded tantalum pentoxide-poly(acrylic acid) nanoparticles for controlled drug release applications.

Autor: Bogusz K; Institute for Superconducting and Electronic Materials, Australian Institute for Innovative Materials, University of Wollongong, NSW 2522, Australia; Illawarra Health and Medical Research Institute, University of Wollongong, NSW 2522, Australia., Zuchora M; Institute for Superconducting and Electronic Materials, Australian Institute for Innovative Materials, University of Wollongong, NSW 2522, Australia; Illawarra Health and Medical Research Institute, University of Wollongong, NSW 2522, Australia., Sencadas V; School of Mechanical, Materials, Mechatronics and Biomedical Engineering, Faculty of Engineering and Information Science, University of Wollongong, NSW 2522, Australia; ARC Center of Excellence for Electromaterials Science, University of Wollongong, NSW 2522, Australia. Electronic address: victors@uow.edu.au., Tehei M; Illawarra Health and Medical Research Institute, University of Wollongong, NSW 2522, Australia; Centre for Medical Radiation Physics, Faculty of Engineering and Information Science, University of Wollongong, NSW 2522, Australia., Lerch M; Illawarra Health and Medical Research Institute, University of Wollongong, NSW 2522, Australia; Centre for Medical Radiation Physics, Faculty of Engineering and Information Science, University of Wollongong, NSW 2522, Australia., Thorpe N; Centre for Medical Radiation Physics, Faculty of Engineering and Information Science, University of Wollongong, NSW 2522, Australia., Rosenfeld A; Illawarra Health and Medical Research Institute, University of Wollongong, NSW 2522, Australia; Centre for Medical Radiation Physics, Faculty of Engineering and Information Science, University of Wollongong, NSW 2522, Australia., Dou SX; Institute for Superconducting and Electronic Materials, Australian Institute for Innovative Materials, University of Wollongong, NSW 2522, Australia., Liu HK; Institute for Superconducting and Electronic Materials, Australian Institute for Innovative Materials, University of Wollongong, NSW 2522, Australia., Konstantinov K; Institute for Superconducting and Electronic Materials, Australian Institute for Innovative Materials, University of Wollongong, NSW 2522, Australia; Illawarra Health and Medical Research Institute, University of Wollongong, NSW 2522, Australia. Electronic address: konstan@uow.edu.au.
Jazyk: angličtina
Zdroj: Journal of colloid and interface science [J Colloid Interface Sci] 2019 Mar 07; Vol. 538, pp. 286-296. Date of Electronic Publication: 2018 Nov 26.
DOI: 10.1016/j.jcis.2018.11.097
Abstrakt: Over the past decade, there has been increasing interest in the use of multifunctional nanoparticles (NPs) for cancer treatment. Of importance are systems that can deliver drugs at a sustained rate to target cancer cells, which can result in higher efficiency and reduced systemic toxicity. In this study, we present the route for the synthesis of tantalum pentoxide (Ta 2 O 5 ) NPs with a particle size of 27 nm that were individually coated with poly(acrylic acid) (PAA) with a different layer thickness of 2-8 nm by in-situ polymerization of the acrylic acid monomer. The capability of Ta 2 O 5 -PAA to provide anatomical contrast-enhancing features has been demonstrated via computed tomography. The Ta 2 O 5 -PAA conjugate was further loaded with methotrexate, and the drug release was observed for a total of 72 h at a pH of 3.6, 5.4, 7.4, and 9.4. While the different layer thicknesses did not influence the drug release kinetics, a decrease in pH of the release medium resulted in a slower drug release. The developed nanocomposite particles present a great potential as a theranostic system for biomedical applications.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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