A sensitive and accurate vortex-assisted liquid-liquid microextraction-gas chromatography-mass spectrometry method for urinary triazoles.

Autor: Machado SC; Laboratory of Toxicants and Drugs Analysis - LATF, Faculty of Pharmaceutical Sciences, Federal University of Alfenas - Unifal-MG, Gabriel Monteiro da Silva street, 700, 37130-000 Alfenas, MG, Brazil., Souza BM; Laboratory of Toxicants and Drugs Analysis - LATF, Faculty of Pharmaceutical Sciences, Federal University of Alfenas - Unifal-MG, Gabriel Monteiro da Silva street, 700, 37130-000 Alfenas, MG, Brazil., de Aguiar Marciano LP; Laboratory of Toxicants and Drugs Analysis - LATF, Faculty of Pharmaceutical Sciences, Federal University of Alfenas - Unifal-MG, Gabriel Monteiro da Silva street, 700, 37130-000 Alfenas, MG, Brazil., Souza Pereira AF; Laboratory of Toxicants and Drugs Analysis - LATF, Faculty of Pharmaceutical Sciences, Federal University of Alfenas - Unifal-MG, Gabriel Monteiro da Silva street, 700, 37130-000 Alfenas, MG, Brazil., de Carvalho DT; Laboratory of Toxicants and Drugs Analysis - LATF, Faculty of Pharmaceutical Sciences, Federal University of Alfenas - Unifal-MG, Gabriel Monteiro da Silva street, 700, 37130-000 Alfenas, MG, Brazil., Martins I; Laboratory of Toxicants and Drugs Analysis - LATF, Faculty of Pharmaceutical Sciences, Federal University of Alfenas - Unifal-MG, Gabriel Monteiro da Silva street, 700, 37130-000 Alfenas, MG, Brazil. Electronic address: isarita.sakakibara@unifal-mg.edu.br.
Jazyk: angličtina
Zdroj: Journal of chromatography. A [J Chromatogr A] 2019 Feb 08; Vol. 1586, pp. 9-17. Date of Electronic Publication: 2018 Nov 30.
DOI: 10.1016/j.chroma.2018.11.082
Abstrakt: The development and validation of an innovative, simple, rapid, selective and sensitive vortex-assisted liquid-liquid microextraction-gas chromatography- mass spectrometry (VALLME-GC/MS) method to seven triazole fungicides in urine is reported. The confidence parameters were exhaustive evaluated and linearity (r > 0.99), precision (below 15%, to quality controls, and 20%, to lower limit of quantification), accuracy and robustness were adequate for the analysis of cyproconazole, epoxiconazole, metconazole, tebuconazole, triadimenol, propiconazole and triadimefon. To assess the applicability of the method, analyses were performed in volunteers exposed to triazoles in the last 30 days. The method demonstrated satisfactory analytical performance, with sufficient detectability to be applied as a potential tool to biomonitoring individuals exposed to the seven evaluated fungicides.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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