Structural Insights into the Mechanism of Dynamin Superfamily Proteins.

Autor: Jimah JR; Structural Cell Biology Section, Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA., Hinshaw JE; Structural Cell Biology Section, Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address: jennyh@niddk.nih.gov.
Jazyk: angličtina
Zdroj: Trends in cell biology [Trends Cell Biol] 2019 Mar; Vol. 29 (3), pp. 257-273. Date of Electronic Publication: 2018 Dec 05.
DOI: 10.1016/j.tcb.2018.11.003
Abstrakt: Dynamin superfamily proteins (DSPs) mediate membrane fission and fusion necessary for endocytosis, organelle biogenesis and maintenance, as well as for bacterial cytokinesis. They also function in the innate immune response to pathogens and in organizing the cytoskeleton. In this review, we summarize the current understanding of the molecular mechanism of DSPs, with emphasis on the structural basis of function. Studies from the past decade on the structure and mechanism of DSPs enable comparative analysis of shared mechanisms and unique features of this protein family.
(Copyright © 2018. Published by Elsevier Ltd.)
Databáze: MEDLINE
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