50-foot walking time: a critical assessment of an outcome measure in clinical therapeutic trials of antirheumatic drugs.

Autor: Grace EM; Department of Rheumatology, McMaster University Health Sciences Centre, Chedoke McMaster Hospitals, Hamilton, Ontario, Canada., Gerecz EM, Kassam YB, Buchanan HM, Buchanan WW, Tugwell PS
Jazyk: angličtina
Zdroj: British journal of rheumatology [Br J Rheumatol] 1988 Oct; Vol. 27 (5), pp. 372-4.
DOI: 10.1093/rheumatology/27.5.372
Abstrakt: Fifty-foot walking time was used in 51 of 187 clinical therapeutic trials of antirheumatic drugs and in only 21 instances was statistical significance reached. Measurement of the 50-foot walking time showed no better performance in long-term trials of SAARDs than in short-term trials of NSAIDs. It is concluded that the 50-foot walking time is a poor outcome measure in rheumatic disease trials, despite a high intra- and interobserver reproducibility.
Databáze: MEDLINE