| Autor: |
Guzii AG; G. B. Elyakov Pacific Institute of Bioorganic Chemistry , Far Eastern Branch of the Russian Academy of Sciences , Prospect 100-let Vladivostoku 159 , Vladivostok 690022 , Russian Federation., Makarieva TN; G. B. Elyakov Pacific Institute of Bioorganic Chemistry , Far Eastern Branch of the Russian Academy of Sciences , Prospect 100-let Vladivostoku 159 , Vladivostok 690022 , Russian Federation., Denisenko VA; G. B. Elyakov Pacific Institute of Bioorganic Chemistry , Far Eastern Branch of the Russian Academy of Sciences , Prospect 100-let Vladivostoku 159 , Vladivostok 690022 , Russian Federation., Dmitrenok PS; G. B. Elyakov Pacific Institute of Bioorganic Chemistry , Far Eastern Branch of the Russian Academy of Sciences , Prospect 100-let Vladivostoku 159 , Vladivostok 690022 , Russian Federation., Popov RS; G. B. Elyakov Pacific Institute of Bioorganic Chemistry , Far Eastern Branch of the Russian Academy of Sciences , Prospect 100-let Vladivostoku 159 , Vladivostok 690022 , Russian Federation., Kuzmich AS; G. B. Elyakov Pacific Institute of Bioorganic Chemistry , Far Eastern Branch of the Russian Academy of Sciences , Prospect 100-let Vladivostoku 159 , Vladivostok 690022 , Russian Federation., Fedorov SN; G. B. Elyakov Pacific Institute of Bioorganic Chemistry , Far Eastern Branch of the Russian Academy of Sciences , Prospect 100-let Vladivostoku 159 , Vladivostok 690022 , Russian Federation., Krasokhin VB; G. B. Elyakov Pacific Institute of Bioorganic Chemistry , Far Eastern Branch of the Russian Academy of Sciences , Prospect 100-let Vladivostoku 159 , Vladivostok 690022 , Russian Federation., Kim NY; G. B. Elyakov Pacific Institute of Bioorganic Chemistry , Far Eastern Branch of the Russian Academy of Sciences , Prospect 100-let Vladivostoku 159 , Vladivostok 690022 , Russian Federation., Stonik VA; G. B. Elyakov Pacific Institute of Bioorganic Chemistry , Far Eastern Branch of the Russian Academy of Sciences , Prospect 100-let Vladivostoku 159 , Vladivostok 690022 , Russian Federation. |
| Abstrakt: |
Melonoside B (1) and melonosins B (2) and A (3), new lipids based on polyoxygenated fatty acid amides, and known melonoside A (4) were isolated from two different collections of the marine sponge Melonanchora kobjakovae. The structures of these compounds, including their absolute configurations, were established using detailed analysis of 1D and 2D NMR, ECD, and mass spectra as well as chemical transformations. Melonosins 2 and 3 inhibit AP-1- and NF-kB-dependent transcriptional activities in JB6 Cl41 cells at noncytotoxic concentrations, demonstrating potential cancer preventive activity. |
