The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio as a predictor of insulin resistance, β-cell function, and diabetes in Hispanics and African Americans.

Autor: Young KA; Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States of America., Maturu A; OhioHealth, Columbus, OH 43235, United States of America., Lorenzo C; Department of Medicine, University of Texas Health Sciences Center, San Antonio, TX 78229, United States of America., Langefeld CD; Center for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, NC 27157, United States of America., Wagenknecht LE; Center for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, NC 27157, United States of America., Chen YI; Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles, CA 90502, United States of America., Taylor KD; Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles, CA 90502, United States of America., Rotter JI; Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles, CA 90502, United States of America., Norris JM; Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States of America., Rasouli N; Division of Endocrinology, Diabetes and Metabolism, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States of America; VA Eastern Colorado Health Care System, Denver, CO 80220, United States of America. Electronic address: neda.rasouli@ucdenver.edu.
Jazyk: angličtina
Zdroj: Journal of diabetes and its complications [J Diabetes Complications] 2019 Feb; Vol. 33 (2), pp. 118-122. Date of Electronic Publication: 2018 Nov 03.
DOI: 10.1016/j.jdiacomp.2018.10.018
Abstrakt: Objective: The TG/HDL-C ratio is used as a marker of insulin resistance (IR) in Caucasians; however, there is limited data in other ethnic groups. We hypothesized that the TG/HDL-C ratio is associated with IR in Hispanics and African Americans (AA).
Research Design and Methods: Data from the Insulin Resistance Atherosclerosis Family Study was examined for associations between TG/HDL-C ratio and IR, β-cell function and incident diabetes in non-diabetic Hispanics (n = 872, 63% female) and AA (n = 371, 61% female). Insulin sensitivity index (S I ) and disposition index (DI) from frequently-sampled intravenous glucose tolerance tests were used as markers of IR and β-cell function respectively. Incident type 2 diabetes was determined by fasting glucose ≥ 126 mg/dl or initiation of anti-hyperglycemia agents over 5 year follow-up.
Results: Higher TG/HDL-C ratio was associated with IR in Hispanic and AA men and women (P < 0.0002), as well as β-cell function in Hispanic women and AA men and women (P < 0.02). TG/HDL-C predicted incident type 2 diabetes in women (area under the curves 0.703 and 0.795 for Hispanics and AA respectively).
Conclusions: Similar to Caucasians, the TG/HDL-C ratio can be used to identify IR in Hispanics and AA, and may predict type 2 diabetes in women.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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