Association of pre-eclampsia risk with maternal levels of folate, homocysteine and vitamin B12 in Colombia: A case-control study.

Autor: Serrano NC; Fundación Cardiovascular de Colombia, Floridablanca, Colombia.; Hospital Internacional de Colombia, Piedecuesta, Colombia.; Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia., Quintero-Lesmes DC; Fundación Cardiovascular de Colombia, Floridablanca, Colombia.; Hospital Internacional de Colombia, Piedecuesta, Colombia., Becerra-Bayona S; Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia., Guio E; Fundación Cardiovascular de Colombia, Floridablanca, Colombia., Beltran M; Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia.; Universidad Industrial de Santander, Bucaramanga, Colombia., Paez MC; Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia., Ortiz R; Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia., Saldarriaga W; Departamento de Ginecología y Obstetricia, Departamento de Morfología, Facultad de Salud, Universidad del Valle, Cali, Colombia., Diaz LA; Universidad Industrial de Santander, Bucaramanga, Colombia., Monterrosa Á; Universidad de Cartagena, Cartagena, Colombia., Miranda J; Universidad de Cartagena, Cartagena, Colombia., Mesa CM; Universidad CES, Medellín, Colombia., Sanin JE; Universidad Pontificia Bolivariana, Bucaramanga, Colombia., Monsalve G; Universidad Pontificia Bolivariana, Bucaramanga, Colombia., Dudbridge F; Department of Health Sciences, Centre for Medicine, University of Leicester, Leicester, United Kingdom., Hingorani AD; Farr Institute of Health Informatics, University College London, London, United Kingdom., Casas JP; Farr Institute of Health Informatics, University College London, London, United Kingdom.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2018 Dec 06; Vol. 13 (12), pp. e0208137. Date of Electronic Publication: 2018 Dec 06 (Print Publication: 2018).
DOI: 10.1371/journal.pone.0208137
Abstrakt: Background: Maternal serum concentrations of folate, homocysteine, and vitamin B12 have been associated with pre-eclampsia. Nevertheless, reported studies involve limited number of cases to reliably assess the nature of these associations. Our aim was to examine the relation of these three biomarkers with pre-eclampsia risk in a large Colombian population.
Materials and Methods: Design: A case-control study. Setting: Cases of pre-eclampsia and healthy pregnant controls were recruited at the time of delivery from eight different Colombian cities between 2000 and 2012. Population or Sample: 2978 cases and 4096 controls were studied. Maternal serum concentrations of folate, homocysteine, and vitamin B12 were determined in 1148 (43.6%) cases and 1300 (31.7%) controls. Also, self-reported folic acid supplementation was recorded for 2563 (84%) cases and 3155 (84%) controls. Analysis: Adjusted odds ratios (OR) for pre-eclampsia were estimated for one standard deviation (1SD) increase in log-transformed biomarkers. Furthermore, we conducted analyses to compare women that reported taking folic acid supplementation for different periods during pregnancy. Main Outcomes Measures: Odds ratio for pre-eclampsia.
Results: After adjusting for potential confounders in logistic regression models, the OR for pre-eclampsia was 0.80 (95% CI: 0.72, 0.90) for 1SD increase in log-folate, 1.16 (95%CI: 1.05, 1.27) for 1SD increase in log-homocysteine, and 1.10 (95%CI: 0.99, 1.22) for 1SD increase in log-vitamin B12. No interactions among the biomarkers were identified. Women who self-reported consumption of folic acid (1 mg/day) throughout their pregnancy had an adjusted OR for pre-eclampsia of 0.86 (95%CI: 0.67, 1.09) compared to women that reported no consumption of folic acid at any point during pregnancy.
Conclusions: Maternal serum concentrations of folate were associated as a protective factor for pre-eclampsia while concentrations of homocysteine were associated as a risk factor. No association between maternal vitamin B12 concentrations and preeclampsia was found.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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