Microbiota profile in new-onset pediatric Crohn's disease: data from a non-Western population.

Autor: El Mouzan MI; 1Pediatric IBD Research Group, Gastroenterology Division, Department of Pediatrics, King Saud University, P. O. Box 2925, Riyadh, 11461 Kingdom of Saudi Arabia., Winter HS; Mass General Hospital for Children, Pediatric IBD Program Boston, Boston, USA., Assiri AA; 3Department of Pediatrics, Gastroenterology Division, Prince Abdullah Bin Khalid Celiac Disease Research Chair, King Saud University, Riyadh, Kingdom of Saudi Arabia., Korolev KS; 4Physics Department and Bioinformatics Program, Boston University, Boston, USA., Al Sarkhy AA; 3Department of Pediatrics, Gastroenterology Division, Prince Abdullah Bin Khalid Celiac Disease Research Chair, King Saud University, Riyadh, Kingdom of Saudi Arabia., Dowd SE; MRDNA Research, Shallowater, TX USA., Al Mofarreh MA; Department of Gastroenterology, Al Mofarreh Polyclinic, Riyadh, Kingdom of Saudi Arabia., Menon R; 7Physics Department, Boston University, Boston, USA.
Jazyk: angličtina
Zdroj: Gut pathogens [Gut Pathog] 2018 Nov 29; Vol. 10, pp. 49. Date of Electronic Publication: 2018 Nov 29 (Print Publication: 2018).
DOI: 10.1186/s13099-018-0276-3
Abstrakt: Background: The role of microbiota in Crohn's disease (CD) is increasingly recognized. However, most of the reports are from Western populations. Considering the possible variation from other populations, the aim of this study was to describe the microbiota profile in children with CD in Saudi Arabia, a non-Western developing country population.
Results: Significantly more abundant genera in children with CD included Fusobacterium, Peptostreptococcus, Psychrobacter, and Acinetobacter; whereas the most significantly-depleted genera included Roseburia, Clostridium, Ruminococcus, Ruminoclostridium, Intestinibacter, Mitsuokella, Megasphaera, Streptococcus, Lactobacillus, Turicibacter, and Paludibacter. Alpha diversity was significantly reduced in stool (p = 0.03) but not in mucosa (p = 0.31). Beta diversity showed significant difference in community composition between control and CD samples (p = 0.03).
Conclusion: In this developing country, we found a pattern of microbiota in children with CD similar to Western literature, suggesting a role of recent dietary lifestyle changes in this population on microbiota structure.
Databáze: MEDLINE
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