Efficacy of a repair cream containing Rhealba oat plantlets extract l-ALA-l-GLU dipeptide, and hyaluronic acid in wound healing following dermatological acts: a meta-analysis of >2,000 patients in eight countries corroborated by a dermatopediatric clinical case.

Autor:	Saint Aroman M; Pierre Fabre Dermo-Cosmétique, A-DERMA, Lavaur, France, marketa.saint.aroman@pierre-fabre.com., Guillot P; Wallerstein Medico-Surgical Center, Dermatology Department, Arès, France., Dahan S; Saint-Jean du Languedoc Clinic, Dermatology Department, Toulouse, France., Coustou D; Saint-Jean du Languedoc Clinic, Dermatology Department, Toulouse, France., Mortazawi K; Clinic for Pediatric Surgery, Hospital Karlsruhe GmbH, Karlsruhe, Germany., Zourabichvili O; Quanta Medical, Rueil-Malmaison, France., Aardewijn T; Pierre Fabre Dermo-Cosmétique, A-DERMA, Lavaur, France, marketa.saint.aroman@pierre-fabre.com.
Jazyk:	angličtina
Zdroj:	Clinical, cosmetic and investigational dermatology [Clin Cosmet Investig Dermatol] 2018 Nov 13; Vol. 11, pp. 579-589. Date of Electronic Publication: 2018 Nov 13 (Print Publication: 2018).
DOI:	10.2147/CCID.S177614
Abstrakt:	Background: The frequency of dermatological acts is increasing. These procedures often cause injuries and traumatic alterations in specific skin layers, slowing down wound healing. Patients and Methods: An open observational study lasting 1 month was conducted on 2,363 patients who had undergone various dermatological procedures. This study was conducted in eight European countries and an Asian country during which the tolerance and efficacy of a cosmetic cream based on Rhealba oat plantlets' extract, l-ALA-l-GLU dipeptide, and hyaluronic acid were assessed on patients' wounds. Results: Efficacy was observed 5' after the first application, which leads to an immediate relief, confirmed by the overall efficacy judged by the doctors as good or very good in 96.8% of the cases. In Germany, the efficacy of the same cream was assessed on children suffering from first- or second-degree burns. In this dermatopediatric case, the aim was to support the regeneration process and prevent scarring by using a topical cream rather than a silicon bandage or corticosteroids. A positive effect on skin regeneration and prevention of scaring could already be observed after 4 weeks of application without any undesired complication. Conclusion: This clinical focus complements the previous meta-analysis by demonstrating that the tested cream containing Rhealba oat plantlets' extracts, l-ALA-l-GLU dipeptide, and hyaluronic acid could also be used with a great efficacy in children after thermal burns to prevent scaring. Competing Interests: Disclosure MSA is the medical director of A-DERMA Dermatological Laboratories and an employee of Pierre Fabre Dermo-Cos-métique, which sponsored the clinical trial. TA is intern at Pierre Fabre Dermo-Cosmétique but is affiliated to Université Toulouse III. OZ is the CEO of Quanta Medical, recruited by Pierre Fabre Dermo-Cosmétique for the statistical services and the meta-analysis. All other authors report no conflicts of interest in this work.
Databáze:	MEDLINE
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