Association between brown adipose tissue and bone mineral density in humans.

Autor: Sanchez-Delgado G; PROFITH 'PROmoting FITness and Health through physical activity' research group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Ctra. de Alfacar s/n, C.P., 18071, Granada, Spain. gsanchezdelgado@ugr.es., Martinez-Tellez B; PROFITH 'PROmoting FITness and Health through physical activity' research group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Ctra. de Alfacar s/n, C.P., 18071, Granada, Spain.; Department of Medicine, Division of Endocrinology, and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Albinusdreef 2, 2333, Leiden, The Netherlands., Garcia-Rivero Y; Nuclear Medicine Department, 'Virgen de las Nieves' University Hospital, Granada, Spain.; Biohealth Research Institute in Granada (ibs.GRANADA), Granada, Spain., Acosta FM; PROFITH 'PROmoting FITness and Health through physical activity' research group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Ctra. de Alfacar s/n, C.P., 18071, Granada, Spain., Alcantara JMA; PROFITH 'PROmoting FITness and Health through physical activity' research group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Ctra. de Alfacar s/n, C.P., 18071, Granada, Spain., Amaro-Gahete FJ; PROFITH 'PROmoting FITness and Health through physical activity' research group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Ctra. de Alfacar s/n, C.P., 18071, Granada, Spain.; Department of Medical Physiology. School of Medicine, University of Granada, Granada, Spain., Llamas-Elvira JM; Nuclear Medicine Department, 'Virgen de las Nieves' University Hospital, Granada, Spain.; Biohealth Research Institute in Granada (ibs.GRANADA), Granada, Spain., Gracia-Marco L; PROFITH 'PROmoting FITness and Health through physical activity' research group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Ctra. de Alfacar s/n, C.P., 18071, Granada, Spain.; Growth, Exercise, NUtrition and Development (GENUD) Research Group, Universidad de Zaragoza, Zaragoza, Spain., Ruiz JR; PROFITH 'PROmoting FITness and Health through physical activity' research group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Ctra. de Alfacar s/n, C.P., 18071, Granada, Spain.
Jazyk: angličtina
Zdroj: International journal of obesity (2005) [Int J Obes (Lond)] 2019 Aug; Vol. 43 (8), pp. 1516-1525. Date of Electronic Publication: 2018 Dec 05.
DOI: 10.1038/s41366-018-0261-4
Abstrakt: Background: Brown adipose tissue (BAT) seems to play a role in bone morphogenesis. A negative association has been reported between BAT and bone mineral density (BMD) in women, but not in men. A panel of experts has recently published a set of recommendations for BAT assessment, and thus, to re-address previously reported associations is needed. This study aimed to investigate the association between cold-induced BAT 18 F-Fluorodeoxyglucose ( 18 F-FDG) uptake and BMD in young healthy adults.
Methods: Ninety-eight healthy adults (68 women; 22 ± 2.2 years old; 24.3 ± 4.5 kg/m 2 ) cold-induced BAT was assessed by means of an 18 F-FDG positron emission tomography-computed tomography (PET-CT) scan preceded by a personalized cold stimulation. The cold exposure consisted in 2 h in a mild cold room at 19.5-20 °C wearing a water perfused cooling vest set 4 °C above the individual shivering threshold. Total body and lumbar spine BMD were assessed by a whole-body DXA scan.
Results: We found no association between BMD and cold-induced BAT volume, mean, and maximal activity (all P > 0.1) in neither young and healthy men nor women. These results remained unchanged when adjusting by height, by body composition, and by objectively assessed physical activity. Sensitivity analyses using the criteria to quantify cold-induced BAT-related parameters applied in previous studies did not change the results.
Conclusions: In summary, our study shows that there is no association between cold-induced BAT and BMD in young healthy adults. Moreover, our data support the notion that previously shown associations between BAT and BMD in healthy non-calorically restricted individuals, could be driven by methodological issues related to BAT assessment and/or sample size limitations.
Databáze: MEDLINE
Externí odkaz: