The course of neuropsychiatric symptoms in patients with dementia in primary care.

Autor:	Borsje P; Department of Primary and Community Care, Center for Family Medicine, Geriatric Care and Public Health, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, The Netherlands.; Thebe, Region South-East, Goirle, The Netherlands., Lucassen PLBJ; Department of Primary and Community Care, Center for Family Medicine, Geriatric Care and Public Health, Radboud University Medical Center, Nijmegen, The Netherlands., Bor H; Department of Primary and Community Care, Center for Family Medicine, Geriatric Care and Public Health, Radboud University Medical Center, Nijmegen, The Netherlands., Wetzels RB; Department of Primary and Community Care, Center for Family Medicine, Geriatric Care and Public Health, Radboud University Medical Center, Nijmegen, The Netherlands., Pot AM; Department of Clinical Psychology, VU University Amsterdam, Amsterdam, The Netherlands.; Netherlands Institute of Mental Health and Addiction, Utrecht, The Netherlands.; School of Psychology, The University of Queensland, St Lucia, Australia., Koopmans RTCM; Department of Primary and Community Care, Center for Family Medicine, Geriatric Care and Public Health, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, The Netherlands.; Joachim and Anna, Centre for Specialized Geriatric Care, Nijmegen, The Netherlands.
Jazyk:	angličtina
Zdroj:	Family practice [Fam Pract] 2019 Jul 31; Vol. 36 (4), pp. 437-444.
DOI:	10.1093/fampra/cmy117
Abstrakt:	Background: During the course of dementia, most people develop some type of neuropsychiatric symptoms (NPS), which result in lower quality of life, high caregiver burden, psychotropic drug use and a major risk of institutionalization. Studies on NPS in people with dementia have been mainly conducted in clinical centres or psychiatric services. Objectives: To investigate the course of NPS in people with dementia in primary care. Methods: Analysis of (cumulative) prevalence and incidence, persistence and resolution based on data collected during an assessment at home of a prospective naturalistic cohort study in primary care in a sample of 117 people with dementia and their informal caregivers. Subsyndromes of NPS were assessed with the Neuropsychiatric Inventory (NPI) and Cohen-Mansfield Agitation Inventory. Multivariate analyses were used to detect determinants for the course of NPS. Results: The mean age of the people with dementia was 78.6 years, and 52% were female. Mean Mini-Mental State Examination total score was 19.5, mean NPI total score 15.7. The most prevalent clinically relevant subsyndromes of the NPI were hyperactivity and mood/apathy, and the most prevalent individual NPS were aberrant motor behaviour (28%), agitation/aggression (24%) and apathy/indifference (22%). Of the people with dementia, 72.3% had one or more symptoms of the mood/apathy and 75.3% of the hyperactivity subsyndrome. Conclusions: GPs should be aware of NPS in people with dementia and should actively identify them when they visit these patients or when informal caregivers consult them. Timely diagnosing facilitates adequate professional care. (© The Author(s) 2018. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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