Polyclonal anti T-lymphocyte antibody therapy monitoring in kidney transplant recipients: comparison of CD3+ T cell and total lymphocyte counts.

Autor: Machado FP; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.; Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil., Vicari AR; Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil., Spuldaro F; Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil., Castro Filho JBS; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.; Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil., Manfro RC; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.; Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
Jazyk: English; Portuguese
Zdroj: Einstein (Sao Paulo, Brazil) [Einstein (Sao Paulo)] 2018 Nov 29; Vol. 16 (4), pp. eAO4278. Date of Electronic Publication: 2018 Nov 29.
DOI: 10.31744/einstein_journal/2018AO4278
Abstrakt: Objective: To investigate the correlation between total lymphocyte and CD3+ T cell counts in peripheral blood in renal transplant patients treated with anti-thymocyte globulin, and discuss related outcomes.
Methods: A single-center, retrospective study involving 226 patients submitted to kidney transplant between 2008 and 2013, and treated with anti-thymocyte globulin for induction or treatment of cellular rejection. Doses were adjusted according to CD3+ T cell or total lymphocyte counts in peripheral blood.
Results: A total of 664 paired samples were analyzed. The Spearman's correlation coefficient was 0.416 (p<0.001) for all samples combined; the overall Kappa coefficient was 0.267 (p<0.001). Diagnostic parameters estimated based on total lymphocyte counts were also calculated using the number of CD3+ T cells (gold standard), with a cut off of >20 cells/mm3.
Conclusion: Total lymphocyte and CD3+ T cell counts in peripheral blood are not equivalent monitoring strategies in anti-thymocyte globulin therapy.
Databáze: MEDLINE
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