Reactive Oxygen Species: the Dual Role in Physiological and Pathological Conditions of the Human Body.

Autor: Bardaweel SK; Department of Pharmaceutical Sciences, University of Jordan School of Pharmacy, Amman, Jordan., Gul M; Department of Physiology, Atatürk University School of Medicine, Erzurum, Turkey., Alzweiri M; Department of Pharmaceutical Sciences, University of Jordan School of Pharmacy, Amman, Jordan., Ishaqat A; Department of Pharmaceutical Sciences, University of Jordan School of Pharmacy, Amman, Jordan., ALSalamat HA; Department of Pharmaceutical Sciences, University of Jordan School of Pharmacy, Amman, Jordan., Bashatwah RM; Department of Pharmaceutical Sciences, University of Jordan School of Pharmacy, Amman, Jordan.
Jazyk: angličtina
Zdroj: The Eurasian journal of medicine [Eurasian J Med] 2018 Oct; Vol. 50 (3), pp. 193-201.
DOI: 10.5152/eurasianjmed.2018.17397
Abstrakt: Reactive oxygen species (ROS) are well-known for playing a dual role as destructive and constructive species. Indeed, ROS are engaged in many redox-governing activities of the cells for the preservation of cellular homeostasis. However, its overproduction has been reported to result in oxidative stress, which is considered as a deleterious process, and is involved in the damage of cell structures that causes various diseased states. This review provides a concise view on some of the current research published in this topic for an improved understanding of the key roles of ROS in diverse conditions of health and disease. Previous research demonstrated that ROS perform as potential signaling molecules to control several normal physiological functions at the cellular level. Additionally, there is a growing body of evidence supporting the role of ROS in various pathological states. The binary nature of ROS with their profitable and injurious characteristics indicates the complexities of their specific roles at a biological compartment and the difficulties in establishing convenient intervention procedures to treat ROS-related diseases.
Competing Interests: Conflict of Interest: Authors have no conflicts of interest to declare.
Databáze: MEDLINE
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