| Autor: |
Tien DD, Giang LNT, Anh DTT, Dung NT, Ha TN, Ha NTT, Phuong HT, Chinh PT, Van Kiem P, Van Tuyen N |
| Jazyk: |
angličtina |
| Zdroj: |
Natural product communications [Nat Prod Commun] 2016 Dec; Vol. 11 (12), pp. 1789-1792. |
| Abstrakt: |
Dihydroartemisinin was converted to its corresponding alkyne-functionalized esters, which were subsequently deployed as substrates for a 'click' chemistry-mediated coupling-with 3'-azido-3'-deoxythydimine (AZT) to furnish novel triazole-artesunate-AZT hybrid compounds. Moreover, various substituted triazole-artemisinin :hybrids were synthesized based on 'click' chemistry between propargyl-substituted derivatives and artemisinin containing a 2-hydroxypropane unit. Fourteen new hybrids were thus successfully prepared and evaluated as cytotoxic agents, revealing an interesting anticancer activity of four triazole-artemisinin derivative hybrids in KB and HepG2 cancer cell lines. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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