Effects of polymorphisms in APOB, APOE, HSD11β1, PLIN4, and ADIPOQ genes on lipid profile and anthropometric variables related to obesity in children and adolescents.

Autor: Gasparin CC; Laboratório de Polimorfismos e Ligação, Departamento de Genética, Universidade Federal do Paraná (UFPR) Curitiba, PR, Brazil., Leite N; Departamento de Educação Física, Universidade Federal do Paraná (UFPR) Curitiba, PR, Brazil., Tureck LV; Laboratório de Polimorfismos e Ligação, Departamento de Genética, Universidade Federal do Paraná (UFPR) Curitiba, PR, Brazil., Souza RLR; Laboratório de Polimorfismos e Ligação, Departamento de Genética, Universidade Federal do Paraná (UFPR) Curitiba, PR, Brazil., Milano-Gai GE; Departamento de Educação Física, Universidade Federal do Paraná (UFPR) Curitiba, PR, Brazil., Silva LR; Departamento de Educação Física, Universidade Federal do Paraná (UFPR) Curitiba, PR, Brazil., Lopes WA; Departamento de Educação Física, Universidade Federal do Paraná (UFPR) Curitiba, PR, Brazil., Furtado-Alle L; Laboratório de Polimorfismos e Ligação, Departamento de Genética, Universidade Federal do Paraná (UFPR) Curitiba, PR, Brazil.
Jazyk: angličtina
Zdroj: Genetics and molecular biology [Genet Mol Biol] 2018 Oct-Dec; Vol. 41 (4), pp. 735-741. Date of Electronic Publication: 2018 Nov 23.
DOI: 10.1590/1678-4685-GMB-2017-0195
Abstrakt: Genes can influence lipid profile and anthropometric variables related to obesity. The present study aimed to verify if variants of the APOE, APOB, ADIPOQ, HSD11β1, and PLIN4 genes are associated with lipid levels or anthropometric variables in a sample comprised of 393 Euro-Brazilian children and adolescents. DNA was genotyped by TaqMan allelic discrimination assay. The ε4 and ε2 alleles of the APOE gene were associated respectively with lower high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels (p=0.015 and p=0.012, respectively), while the ε3 allele was associated with higher abdominal circumference (p=0.0416) and excess weight (p=0.0001). The G allele (rs846910) of the HSD11β1 gene was also associated with excess weight (p=0.039). No other association was found. Our results indicate that the ε4 and ε2 alleles could contribute to lower HDL-C and LDL-C levels, respectively, furthermore, the ε3 allele and the G allele (rs846910) of HSD11β1 gene may be risk factors for excess of weight.These findings are very important because we observed that some genetic variants influence the lipid profile and anthropometric variables early in life.
Databáze: MEDLINE