New insights on occupational exposure and bladder cancer risk: a pooled analysis of two Italian case-control studies.

Autor: Sciannameo V; Unit of Epidemiology, Regional Health Service, ASLTO3, Via Sabaudia 164, 10095, Grugliasco, TO, Italy.; Department of Biological and Clinical Sciences, University of Turin, 10043, Orbassano, TO, Italy., Carta A; Department of Medical-Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, 25123, Brescia, Italy.; University Research Center Integrated Models for Prevention and Protection in Environmental and Occupational Health, University of Brescia, 25123, Brescia, Italy., d'Errico A; Unit of Epidemiology, Regional Health Service, ASLTO3, Via Sabaudia 164, 10095, Grugliasco, TO, Italy., Giraudo MT; Department of Mathematics 'G. Peano', University of Turin, 10123, Turin, Italy., Fasanelli F; Unit of Cancer Epidemiology, CPO Piedmont, Department of Medical Sciences, Città della Salute e della Scienza Hospital, University of Turin, 10126, Turin, Italy., Arici C; University Research Center Integrated Models for Prevention and Protection in Environmental and Occupational Health, University of Brescia, 25123, Brescia, Italy.; Department of Diagnostics and Public Health, University of Verona, 37134, Verona, Italy., Maule M; Unit of Cancer Epidemiology, CPO Piedmont, Department of Medical Sciences, Città della Salute e della Scienza Hospital, University of Turin, 10126, Turin, Italy., Carnà P; Unit of Epidemiology, Regional Health Service, ASLTO3, Via Sabaudia 164, 10095, Grugliasco, TO, Italy., Destefanis P; Unit of Urology U, Città della Salute e della Scienza Hospital, University of Turin, 10126, Turin, Italy., Rolle L; Unit of Urology U, Città della Salute e della Scienza Hospital, University of Turin, 10126, Turin, Italy., Gontero P; Unit of Urology U, Città della Salute e della Scienza Hospital, University of Turin, 10126, Turin, Italy., Casetta G; Unit of Urology U, Città della Salute e della Scienza Hospital, University of Turin, 10126, Turin, Italy., Zitella A; Unit of Urology U, Città della Salute e della Scienza Hospital, University of Turin, 10126, Turin, Italy., Cucchiarale G; Unit of Urology I, Cellini Clinic, 10126, Turin, Italy., Vineis P; Imperial College London, London, W2 1PG, UK., Porru S; University Research Center Integrated Models for Prevention and Protection in Environmental and Occupational Health, University of Brescia, 25123, Brescia, Italy.; Department of Diagnostics and Public Health, University of Verona, 37134, Verona, Italy., Sacerdote C; Unit of Cancer Epidemiology, CPO Piedmont, Department of Medical Sciences, Città della Salute e della Scienza Hospital, University of Turin, 10126, Turin, Italy., Ricceri F; Unit of Epidemiology, Regional Health Service, ASLTO3, Via Sabaudia 164, 10095, Grugliasco, TO, Italy. fulvio.ricceri@unito.it.; Department of Biological and Clinical Sciences, University of Turin, 10043, Orbassano, TO, Italy. fulvio.ricceri@unito.it.
Jazyk: angličtina
Zdroj: International archives of occupational and environmental health [Int Arch Occup Environ Health] 2019 Apr; Vol. 92 (3), pp. 347-359. Date of Electronic Publication: 2018 Nov 30.
DOI: 10.1007/s00420-018-1388-2
Abstrakt: Purpose: The main risk factor for bladder cancer (BC) is cigarette smoking, but also occupational exposure to carcinogens is relevant, causing about 4-10% of BC. We aimed at investigating the association between BC risk, occupations held in the past and exposure to occupational carcinogens, also assessing whether these associations were influenced by tumour grade.
Methods: We pooled data from two Italian case-control studies on male BC, analyzing 893 cases and 978 controls. Occupations were classified using the International Standard Classification of Occupations and exposure to carcinogens was assigned using a validated Job Exposure Matrix. Logistic regression approach was used as well as a semi-Bayesian model, based on a priori information on exposure.
Results: A significantly increased BC risk was found for chemical engineering technicians, postmen, and lathe operators, but only, for the latter, the association remained significant after Bayesian control for type I error. Among carcinogens, cadmium and trichloroethylene were associated with BC. When analyzing data by grade, exposure to these carcinogens was associated with low-grade BC only.
Conclusions: Our results suggest that monitoring workplaces to prevent exposure to carcinogenic agents is still an important task, which should be still given adequate importance in public health.
Databáze: MEDLINE
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