An exploration of concomitant psychiatric disorders in children with autism spectrum disorder.

Autor: Lecavalier L; Ohio State University, Nisonger Center, United States of America. Electronic address: luc.Lecavalier@osumc.edu., McCracken CE; Emory University School of Medicine, Department of Pediatrics, United States of America. Electronic address: courtney.mccracken@emory.edu., Aman MG; Ohio State University, Nisonger Center, United States of America. Electronic address: aman.1@osu.edu., McDougle CJ; Lurie Center for Autism, Massachusetts General Hospital, United States of America. Electronic address: CMcDougle@partners.org., McCracken JT; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at University of California at Los Angeles, United States of America. Electronic address: jmccracken@mednet.ucla.edu., Tierney E; Johns Hopkins University School of Medicine, United States of America. Electronic address: tierney@kennedykrieger.org., Smith T; University of Rochester Medical Center, United States of America. Electronic address: Tristram_Smith@URMC.Rochester.edu., Johnson C; Cleveland Clinic and Learner College of Medicine, United States of America. Electronic address: johnsoc@ccf.org., King B; University of California, San Francisco, Department of Psychiatry, Benioff Children's Hospitals, United States of America. Electronic address: bryan.king@ucsf.edu., Handen B; University of Pittsburgh School of Medicine, United States of America. Electronic address: handenbl@upmc.edu., Swiezy NB; HANDS in Autism Interdisciplinary Training and Resource Center, Indiana University School of Medicine, United States of America. Electronic address: nswiezy@iupui.edu., Eugene Arnold L; Ohio State University, Nisonger Center, United States of America. Electronic address: l.arnold@osumc.edu., Bearss K; University of Washington, Department of Psychiatry and Behavioral Sciences, United States of America. Electronic address: kbearss@u.washington.edu., Vitiello B; Division of Child and Adolescent Neuro-Psychiatry, University of Turin, Italy. Electronic address: bvitiell@unito.it., Scahill L; Emory University School of Medicine, Department of Pediatrics, United States of America. Electronic address: lawrence.scahill@emory.edu.
Jazyk: angličtina
Zdroj: Comprehensive psychiatry [Compr Psychiatry] 2019 Jan; Vol. 88, pp. 57-64. Date of Electronic Publication: 2018 Nov 06.
DOI: 10.1016/j.comppsych.2018.10.012
Abstrakt: Objective: We explored patterns of concomitant psychiatric disorders in a large sample of treatment-seeking children and adolescents with autism spectrum disorder (ASD).
Methods: Participants were 658 children with ASD (age 3-17 years; mean = 7.2 years) in one of six federally-funded multisite randomized clinical trials (RCT) between 1999 and 2014. All children were referred for hyperactivity or irritability. Study designs varied, but all used the Child and Adolescent Symptom Inventory or Early Childhood Inventory to assess Attention Deficit Hyperactivity Disorder (ADHD), Oppositional-Defiant Disorder (ODD), Conduct Disorder (CD), Anxiety Disorders, and Mood Disorders. In addition, several measures in common were used to assess demographic and clinical characteristics.
Results: Of the 658 children, 73% were Caucasian and 59% had an IQ >70. The rates of concomitant disorders across studies were: ADHD 81%, ODD 46%, CD 12%, any anxiety disorder 42%, and any mood disorder 8%. Two or more psychiatric disorders were identified in 66% of the sample. Of those who met criteria for ADHD, 50% also met criteria for ODD and 46% for any anxiety disorder. Associations between types of concomitant disorders and a number of demographic and clinical characteristics are presented.
Conclusion: In this well-characterized sample of treatment-seeking children with ASD, rates of concomitant psychiatric disorders were high and the presence of two or more co-occurring disorders was common. Findings highlight the importance of improving diagnostic practice in ASD and understanding possible mechanisms of comorbidity.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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