Subcapsular Sinus Macrophages: The Seat of Innate and Adaptive Memory in Murine Lymph Nodes.

Autor: Moran I; Immunology Division, Garvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia. Electronic address: i.moran@garvan.org.au., Grootveld AK; Immunology Division, Garvan Institute of Medical Research, Sydney, Australia; Department of Biology and Biochemistry, Faculty of Science, University of Bath, Bath, UK., Nguyen A; Immunology Division, Garvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia., Phan TG; Immunology Division, Garvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia. Electronic address: t.phan@garvan.org.au.
Jazyk: angličtina
Zdroj: Trends in immunology [Trends Immunol] 2019 Jan; Vol. 40 (1), pp. 35-48. Date of Electronic Publication: 2018 Nov 27.
DOI: 10.1016/j.it.2018.11.004
Abstrakt: Subcapsular sinus (SCS) macrophages are strategically positioned at the lymph-tissue interface in the lymph node to trap and present antigen to B cells. Recent murine data has shown that SCS macrophages also prevent the systemic spread of lymph-borne pathogens and are capable of activating a diverse range of innate effector and adaptive memory cells, including follicular memory T cells and memory B cells (B mems ), that are either pre-positioned or rapidly recruited to the subcapsular niche following infection and inflammation. Furthermore, B mems are rapidly reactivated to differentiate into plasma cells in subcapsular proliferative foci (SPF). Thus, understanding how SCS macrophages coordinate both innate and adaptive memory responses in the subcapsular niche can provide new opportunities to bolster immunity against pathogens and cancer.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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