One-pot synthesis of gold nanoparticles embedded in polysaccharide-based hydrogel: Physical-chemical characterization and feasibility for large-scale production.

Autor: Marques MS; Pós-Graduação em Ciências da Saúde, Universidade do Sul de Santa Catarina, 88701-000 Tubarão, SC, Brazil; Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, 90610-000 Porto Alegre, RS, Brazil(1). Electronic address: morgana.marques@unisul.br., Zepon ΚM; Pós-Graduação em Tecnologia de Materiais e Processos Industriais, Universidade Feevale, 93525-075 Novo Hamburgo, RS, Brazil., Heckler JM; Pós-Graduação em Tecnologia de Materiais e Processos Industriais, Universidade Feevale, 93525-075 Novo Hamburgo, RS, Brazil., Morisso FDP; Pós-Graduação em Tecnologia de Materiais e Processos Industriais, Universidade Feevale, 93525-075 Novo Hamburgo, RS, Brazil., da Silva Paula MM; Pós-Graduação em Ciência e Engenharia de Materiais, Universidade Federal do Amazonas, 69077-000 Manaus, AM, Brazil., Κanis LA; Pós-Graduação em Ciências da Saúde, Universidade do Sul de Santa Catarina, 88701-000 Tubarão, SC, Brazil.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2019 Mar 01; Vol. 124, pp. 838-845. Date of Electronic Publication: 2018 Nov 26.
DOI: 10.1016/j.ijbiomac.2018.11.231
Abstrakt: In this study, polysaccharide-based hydrogel wound dressings containing in situ synthesized gold nanoparticles (AuNPs) were prepared by using a simple, fast and green protocol. The prepared hydrogels were characterized with UV-vis and infrared spectroscopy (FT-IR), and dynamic light scattering (DLS). The rheological and swelling properties and the feasibility to scale-up the wound dressing production from the lamination of the prepared hydrogel on non-woven fabric were also investigated. UV-vis spectra confirmed the AuNPs synthesis and the DLS results exhibited an increase in the size of AuNPs with increasing the initial Au 3+ concentration. The rheological analysis showed that the augmentation of the initial Au 3+ concentration reduces the gel viscosity and gelling temperature. Besides, the FT-IR spectra revealed that the AuNPs hinder the intermolecular interactions between kappa-carrageenan (κCG) and locust bean gum (LBG). The feasibility of scale-up the wound dressing production from the prepared hydrogel was confirmed through the lamination tests.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: