As time flies by: Investigating cardiac aging in the short-lived Drosophila model.

Autor: Blice-Baum AC; Science Department, Cabrini University, Radnor, PA, USA. Electronic address: acb424@cabrini.edu., Guida MC; Development, Aging and Regeneration Program, Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, CA, USA. Electronic address: cguida@sbpdiscovery.org., Hartley PS; Bournemouth University, Department of Life and Environmental Science, Talbot Campus, Fern Barrow, Poole, Dorset BH12 5BB, UK. Electronic address: phartley@bournemouth.ac.uk., Adams PD; Development, Aging and Regeneration Program, Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, CA, USA. Electronic address: padams@sbpdiscovery.org., Bodmer R; Development, Aging and Regeneration Program, Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, CA, USA. Electronic address: rolf@sbpdiscovery.org., Cammarato A; Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: acammar3@jhmi.edu.
Jazyk: angličtina
Zdroj: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2019 Jul 01; Vol. 1865 (7), pp. 1831-1844. Date of Electronic Publication: 2018 Nov 27.
DOI: 10.1016/j.bbadis.2018.11.010
Abstrakt: Aging is associated with a decline in heart function across the tissue, cellular, and molecular levels. The risk of cardiovascular disease grows significantly over time, and as developed countries continue to see an increase in lifespan, the cost of cardiovascular healthcare for the elderly will undoubtedly rise. The molecular basis for cardiac function deterioration with age is multifaceted and not entirely clear, and there is a limit to what investigations can be performed on human subjects or mammalian models. Drosophila melanogaster has emerged as a useful model organism for studying aging in a short timeframe, benefitting from a suite of molecular and genetic tools and displaying highly conserved traits of cardiac senescence. Here, we discuss recent advances in our understanding of cardiac aging and how the fruit fly has aided in these developments.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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