In Vitro Study of the Modulatory Effects of Levofloxacin and BCG on Secretion of Proinflammatory Cytokines in Infiltrative Pulmonary Tuberculosis.

Autor: Serebryakova VA; Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia. serebryakova-val@mail.ru., Urazova OI; Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia., Novitsky VV; Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia., Vengerovskii AI; Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia., Kononova TE; Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2018 Dec; Vol. 166 (2), pp. 225-228. Date of Electronic Publication: 2018 Nov 28.
DOI: 10.1007/s10517-018-4319-z
Abstrakt: The effects levofloxacin (fluoroquinolone) and vaccinal BCG strain on cytokine production by blood mononuclear leukocytes was studied in patients with infiltrative pulmonary tuberculosis. Combined treatment with levofloxacin and vaccinal BCG strain suppressed the production of TNFα in drug-resistant pulmonary tuberculosis and production of IL-12 and IFNγ in drug-sensitive tuberculosis.
Databáze: MEDLINE
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