Imaging findings after acute sport-related concussion in American football players: A systematic review.

Autor: Monk SH; Vanderbilt Sports Concussion Center, Vanderbilt University School of Medicine, Nashville, TN, USA. Electronic address: steve.h.monk@vanderbilt.edu., Legarreta AD; Vanderbilt Sports Concussion Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Kirby P; Vanderbilt Sports Concussion Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Brett BL; Vanderbilt Sports Concussion Center, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA; Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, USA., Yengo-Kahn AM; Vanderbilt Sports Concussion Center, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA., Bhatia A; Vanderbilt Sports Concussion Center, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA., Solomon GS; Vanderbilt Sports Concussion Center, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA., Zuckerman SL; Vanderbilt Sports Concussion Center, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Jazyk: angličtina
Zdroj: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [J Clin Neurosci] 2019 Mar; Vol. 61, pp. 28-35. Date of Electronic Publication: 2018 Nov 26.
DOI: 10.1016/j.jocn.2018.11.022
Abstrakt: Sport-related concussion (SRC) has emerged as a major public health problem. The results of brain imaging studies following SRC have raised questions about long-term neurologic health, but the clinical implications of these findings remain unknown. A systematic review of brain imaging findings after SRC was performed utilizing the following inclusion criteria: football players, brain imaging within 6 months of SRC, and sample size >5. Studies were assessed for: 1) methodology, 2) imaging outcomes, and 3) number of positive statistical comparisons. Imaging was classified as immediate (≤1 week post-injury) or subacute (>1 week to 6 months post-injury). Eleven studies met inclusion criteria. Eight of the 11 studies conducted a total of 809 comparisons of brain function, of which 149 (18%) were statistically significant. Nine of the 11 studies (82%) reported positive immediate findings, but were more likely to be subject to recall bias (86% vs. 0%) and to lack baseline advanced brain imaging (78% vs. 50%) than negative studies. Only 3 of 9 studies that reported subacute findings (33%) reported positive results, and these positive studies were also more likely to be subject to recall bias (100% vs. 40%) and to lack baseline advanced brain imaging (100% vs. 67%) than negative studies. The results of the study demonstrate the transitory nature of positive imaging findings and methodological limitations that complicate study interpretation. Further research is required to correlate imaging findings with clinical outcomes.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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