| Autor: |
Morrell CN; Aab Cardiovascular Research Institute, University of Rochester School of Medicine, Rochester, New York 14642, USA; email: Craig_Morrell@urmc.rochester.edu., Pariser DN; Aab Cardiovascular Research Institute, University of Rochester School of Medicine, Rochester, New York 14642, USA; email: Craig_Morrell@urmc.rochester.edu., Hilt ZT; Aab Cardiovascular Research Institute, University of Rochester School of Medicine, Rochester, New York 14642, USA; email: Craig_Morrell@urmc.rochester.edu., Vega Ocasio D; Aab Cardiovascular Research Institute, University of Rochester School of Medicine, Rochester, New York 14642, USA; email: Craig_Morrell@urmc.rochester.edu. |
| Abstrakt: |
Platelets have dual physiologic roles as both cellular mediators of thrombosis and immune modulatory cells. Historically, the thrombotic function of platelets has received significant research and clinical attention, but emerging research indicates that the immune regulatory roles of platelets may be just as important. We now know that in addition to their role in the acute thrombotic event at the time of myocardial infarction, platelets initiate and accelerate inflammatory processes that are part of the pathogenesis of atherosclerosis and myocardial infarction expansion. Furthermore, it is increasingly apparent from recent studies that platelets impact the pathogenesis of many vascular inflammatory processes such as autoimmune diseases, sepsis, viral infections, and growth and metastasis of many types of tumors. Therefore, we must consider platelets as immune cells that affect all phases of immune responses. |
