Histological Disorganization of Spleen Compartments and Severe Visceral Leishmaniasis.

Autor:	Hermida MD; Fundação Oswaldo Cruz, Instituto Gonçalo Moniz, Salvador, Brazil., de Melo CVB; Fundação Oswaldo Cruz, Instituto Gonçalo Moniz, Salvador, Brazil., Lima IDS; Fundação Oswaldo Cruz, Instituto Gonçalo Moniz, Salvador, Brazil., Oliveira GGS; Fundação Oswaldo Cruz, Instituto Gonçalo Moniz, Salvador, Brazil., Dos-Santos WLC; Fundação Oswaldo Cruz, Instituto Gonçalo Moniz, Salvador, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2018 Nov 13; Vol. 8, pp. 394. Date of Electronic Publication: 2018 Nov 13 (Print Publication: 2018).
DOI:	10.3389/fcimb.2018.00394
Abstrakt:	The spleen is a secondary lymphoid organ responsible for immune surveillance against blood-circulating pathogens. Absence of the spleen is associated with increased susceptibility to systemic spread and fatal infection by different pathogens. Severe forms of visceral leishmaniasis are associated with disorganization of spleen compartments where cell interactions essential for splenic immunological function take place. White pulp atrophies, secondary lymphoid follicles and marginal zones vanish, and the boundaries separating white and red pulp blur. Leukocyte populations are reduced or disappear or are replaced by plasma cells. In this paper, we review the published data on spleen disorganization in severe forms of visceral leishmaniasis and propose a histological classification to help the exchange of information among research groups.
Databáze:	MEDLINE
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