Isolation of multidrug-resistant Haemophilus influenzae harbouring multiple exogenous genes from a patient diagnosed with acute sinusitis.

Autor: Hara N; Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Japan; Japan Organization of Occupational Health and Safety (JOHAS), Yokohama Rosai Hospital, Japan., Wajima T; Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Japan., Seyama S; Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Japan., Tanaka E; Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Japan., Shirai A; Japan Organization of Occupational Health and Safety (JOHAS), Yokohama Rosai Hospital, Japan., Shibata M; Japan Organization of Occupational Health and Safety (JOHAS), Yokohama Rosai Hospital, Japan., Natsume Y; Japan Organization of Occupational Health and Safety (JOHAS), Yokohama Rosai Hospital, Japan., Shiro H; Japan Organization of Occupational Health and Safety (JOHAS), Yokohama Rosai Hospital, Japan., Noguchi N; Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Japan. Electronic address: noguchin@toyaku.ac.jp.
Jazyk: angličtina
Zdroj: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy [J Infect Chemother] 2019 May; Vol. 25 (5), pp. 385-387. Date of Electronic Publication: 2018 Oct 25.
DOI: 10.1016/j.jiac.2018.09.015
Abstrakt: In paediatric patients, β-lactams and macrolides are widely used to treat acute otitis media and sinusitis, which are often caused by either Streptococcus pneumoniae or Haemophilus influenzae. However, resistant isolates have emerged and are becoming more prevalent. H. influenzae generally acquires antimicrobial resistance by mutation or by expression of β-lactamase. In this study, we isolated H. influenzae from a paediatric patient diagnosed with acute sinusitis. This strain harboured multiple exogenous resistance genes: bla TEM-1 , mef(A) and tet(M). DNA sequencing suggested that both mef(A) and tet(M) had been transferred from S. pneumoniae or another Streptococcus. This typical outpatient had not been exposed to excessive levels of antibiotics and had no underlying diseases, strongly suggesting that this type of resistant isolate could become more prevalent.
(Copyright © 2018 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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