Geraniol and linalool anticandidal activity, genotoxic potential and embryotoxic effect on zebrafish.

Autor: Singulani JL; Universidade Estadual Paulista Julio de Mesquita Filho, 14800-903, Araraquara, SP, Brazil., Pedroso RS; Universidade de Franca, 14404-600, Franca, SP, Brazil.; Universidade Federal de Uberlândia,38400-902, Uberlândia, MG, Brazil., Ribeiro AB; Universidade de Franca, 14404-600, Franca, SP, Brazil., Nicolella HD; Universidade de Franca, 14404-600, Franca, SP, Brazil., Freitas KS; Universidade de Franca, 14404-600, Franca, SP, Brazil., Damasceno JL; Universidade de Franca, 14404-600, Franca, SP, Brazil., Vieira TM; Universidade de São Paulo, 14040-901, Ribeirão Preto, SP, Brazil., Crotti AE; Universidade de São Paulo, 14040-901, Ribeirão Preto, SP, Brazil., Tavares DC; Universidade de Franca, 14404-600, Franca, SP, Brazil., Martins CH; Universidade de Franca, 14404-600, Franca, SP, Brazil., Mendes-Giannini MJ; Universidade Estadual Paulista Julio de Mesquita Filho, 14800-903, Araraquara, SP, Brazil., Pires RH; Universidade de Franca, 14404-600, Franca, SP, Brazil.
Jazyk: angličtina
Zdroj: Future microbiology [Future Microbiol] 2018 Nov; Vol. 13, pp. 1637-1646. Date of Electronic Publication: 2018 Nov 27.
DOI: 10.2217/fmb-2018-0200
Abstrakt: Aim: Geraniol and linalool are major constituents of the essential oils of medicinal plants.
Materials & Methods: Antifungal activity of geraniol and linalool were evaluated against five Candida species. The genotoxicity of these compounds was evaluated by the cytokinesis-block micronucleus test, and the embryotoxic assays use zebrafish model.
Results: Geraniol and linalool inhibited Candida growth, but geraniol was more effective. The geraniol at concentration of 800 μg/ml and the linalool at concentration of 125 μg/ml significantly increased chromosome damage. Geraniol was more toxic to zebrafish embryo than linalool: LC 50 values were 31.3 and 193.3 μg/ml, respectively.
Conclusion: Geraniol and linalool have anticandidal activity, but they also exert genotoxic and embryotoxic effects at the highest tested concentrations.
Databáze: MEDLINE
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