In utero effects of maternal phthalate exposure on male genital development.

Autor: Wineland RJ; Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, South Carolina., Bloom MS; Departments of Environmental Health Sciences and Epidemiology and Biostatistics, University at Albany, State University of New York, Rensselaer, New York., Cruze L; Wofford College, Spartanburg, South Carolina., Butts CD; Department of Environmental Health Sciences, University at Albany, State University of New York, Rensselaer, New York., Wenzel AG; Marine Biomedicine and Environmental Science, Medical University of South Carolina, Charleston, South Carolina., Unal ER; Department of Obstetrics and Gynecology, Southern Illinois University, Springfield, Illinois., Kohno S; Department of Biology, St. Cloud State University, Saint Cloud, Minnesota., Willan KB; Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, South Carolina., Brock JW; Department of Chemistry, University of North Carolina Asheville, Asheville, North Carolina., Newman RB; Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, South Carolina.
Jazyk: angličtina
Zdroj: Prenatal diagnosis [Prenat Diagn] 2019 Feb; Vol. 39 (3), pp. 209-218. Date of Electronic Publication: 2019 Feb 07.
DOI: 10.1002/pd.5398
Abstrakt: Background: Phthalates are used extensively in commercial and personal care products and maternal exposure is ubiquitous. Phthalates are anti-androgenic, but the potential effects of phthalates on male penile development have not been assessed in utero.
Objective: The study aims to investigate the association between early pregnancy phthalate exposure and fetal penile development, overall and by race.
Methods: Prospective cohort study of women with singleton pregnancies presenting for prenatal ultrasound between 18 and 22 weeks' gestation. Maternal urine samples were assayed for eight phthalate monoester metabolites. We used maternal phthalate levels at 18 to 22 weeks' gestation as predictors of fetal size using multiple linear regression models, adjusted for fetal gestational age, maternal age, race, smoking, and education. We incorporated a phthalate by race interaction into a second set of regression models.
Results: We detected statistically significant race interactions for continuous phthalates with penile width. Race interactions were also suggested for penile length and volume using tertiles of phthalates with point estimates generally positive for whites and negative for African Americans.
Conclusion: Penile development is significantly influenced by race, and the impact of maternal phthalates on penile measurements also varies by race. Maternal phthalate exposure can adversely affect in utero penile growth and development, especially among African Americans.
(© 2018 John Wiley & Sons, Ltd.)
Databáze: MEDLINE
Externí odkaz: