H19X-encoded miR-424(322)/-503 cluster: emerging roles in cell differentiation, proliferation, plasticity and metabolism.

Autor: Wang F; Department of Oncology, The First Affiliated Hospital of Xian Jiaotong University, Xi'an, 710061, Shaanxi, China.; Department of Biology and Biochemistry, University of Houston, Houston, TX, 77204, USA., Liang R; Department of Biology and Biochemistry, University of Houston, Houston, TX, 77204, USA., Tandon N; Department of Biology and Biochemistry, University of Houston, Houston, TX, 77204, USA., Matthews ER; Department of Biology and Biochemistry, University of Houston, Houston, TX, 77204, USA., Shrestha S; Department of Biology and Biochemistry, University of Houston, Houston, TX, 77204, USA., Yang J; Department of Oncology, The First Affiliated Hospital of Xian Jiaotong University, Xi'an, 710061, Shaanxi, China.; Department of Biology and Biochemistry, University of Houston, Houston, TX, 77204, USA., Soibam B; Computer Science and Engineering Technology, University of Houston-Downtown, Houston, TX, 77002, USA., Yang J; Department of Oncology, The First Affiliated Hospital of Xian Jiaotong University, Xi'an, 710061, Shaanxi, China. yangjin@mail.xjtu.edu.cn., Liu Y; Department of Biology and Biochemistry, University of Houston, Houston, TX, 77204, USA. yliu54@uh.edu.
Jazyk: angličtina
Zdroj: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2019 Mar; Vol. 76 (5), pp. 903-920. Date of Electronic Publication: 2018 Nov 24.
DOI: 10.1007/s00018-018-2971-0
Abstrakt: miR-424(322)/-503 are mammal-specific members of the extended miR-15/107 microRNA family. They form a co-expression network with the imprinted lncRNA H19 in tetrapods. miR-424(322)/-503 regulate fundamental cellular processes including cell cycle, epithelial-to-mesenchymal transition, hypoxia and other stress response. They control tissue differentiation (cardiomyocyte, skeletal muscle, monocyte) and remodeling (mammary gland involution), and paradoxically participate in tumor initiation and progression. Expression of miR-424(322)/-503 is governed by unique mechanisms involving sex hormones. Here, we summarize current literature and provide a primer for future endeavors.
Databáze: MEDLINE
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