Piconewton Mechanical Forces Promote Neurite Growth.
| Autor: | Raffa V; The Institute for Medical Science and Technology, University of Dundee, Dundee, United Kingdom; Department of Biology, Università di Pisa, Pisa, Italy. Electronic address: vittoria.raffa@unipi.it., Falcone F; The Institute for Medical Science and Technology, University of Dundee, Dundee, United Kingdom; Department of Biology, Università di Pisa, Pisa, Italy., De Vincentiis S; Department of Biology, Università di Pisa, Pisa, Italy., Falconieri A; Department of Biology, Università di Pisa, Pisa, Italy., Calatayud MP; Instituto de Nanociencia de Aragón, Universidad de Zaragoza, Mariano Esquillor, Zaragoza, Spain., Goya GF; Instituto de Nanociencia de Aragón, Universidad de Zaragoza, Mariano Esquillor, Zaragoza, Spain., Cuschieri A; The Institute for Medical Science and Technology, University of Dundee, Dundee, United Kingdom. |
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| Jazyk: | angličtina |
| Zdroj: | Biophysical journal [Biophys J] 2018 Nov 20; Vol. 115 (10), pp. 2026-2033. Date of Electronic Publication: 2018 Oct 16. |
| DOI: | 10.1016/j.bpj.2018.10.009 |
| Abstrakt: | Investigations over half a century have indicated that mechanical forces induce neurite growth, with neurites elongating at a rate of 0.1-0.3 μm h -1 pN -1 when mechanical force exceeds a threshold, with this being identified as 400-1000 pN for neurites of PC12 cells. In this article, we demonstrate that neurite elongation of PC12 cells proceeds at the same previously identified rate on application of mechanical tension of ∼1 pN, which is significantly lower than the force generated in vivo by axons and growth cones. This observation raises the possibility that mechanical tension may act as an endogenous signal used by neurons for promoting neurite elongation. (Copyright © 2018 Biophysical Society. Published by Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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