MR fingerprinting enables quantitative measures of brain tissue relaxation times and myelin water fraction in the first five years of life.
Autor: | Chen Y; Departments of Radiology, University of North Carolina, Chapel Hill, NC, USA; Biomedical Research Imaging Center (BRIC), University of North Carolina at Chapel Hill, NC, USA., Chen MH; Chang Gung University College of Medicine, Kaohsiung, Taiwan., Baluyot KR; Biomedical Research Imaging Center (BRIC), University of North Carolina at Chapel Hill, NC, USA., Potts TM; Biomedical Research Imaging Center (BRIC), University of North Carolina at Chapel Hill, NC, USA., Jimenez J; Biomedical Research Imaging Center (BRIC), University of North Carolina at Chapel Hill, NC, USA., Lin W; Departments of Radiology, University of North Carolina, Chapel Hill, NC, USA; Biomedical Research Imaging Center (BRIC), University of North Carolina at Chapel Hill, NC, USA. Electronic address: Weili_lin@med.unc.edu. |
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Jazyk: | angličtina |
Zdroj: | NeuroImage [Neuroimage] 2019 Feb 01; Vol. 186, pp. 782-793. Date of Electronic Publication: 2018 Nov 22. |
DOI: | 10.1016/j.neuroimage.2018.11.038 |
Abstrakt: | Quantitative assessments of normative brain development using MRI are of critical importance to gain insights into healthy neurodevelopment. However, quantitative MR imaging poses significant technical challenges and requires prohibitively long acquisition times, making it impractical for pediatric imaging. This is particularly relevant for healthy subjects, where imaging under sedation is not clinically indicated. MR Fingerprinting (MRF), a novel MR imaging framework, provides rapid, efficient, and simultaneous quantification of multiple tissue properties. In this study, a 2D MR Fingerprinting method was developed that achieves a spatial resolution of 1 × 1 × 3 mm 3 with rapid and simultaneous quantification of T (Copyright © 2018. Published by Elsevier Inc.) |
Databáze: | MEDLINE |
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