Hypoglossal schwannomas: A systematic review of the literature.

Autor: Bindal S; Department of Neurological Surgery, The University of Texas Southwestern, Dallas, TX, United States., El Ahmadieh TY; Department of Neurological Surgery, The University of Texas Southwestern, Dallas, TX, United States. Electronic address: tarek.elahmadieh@phhs.org., Plitt A; Department of Neurological Surgery, The University of Texas Southwestern, Dallas, TX, United States., Aoun SG; Department of Neurological Surgery, The University of Texas Southwestern, Dallas, TX, United States., Neeley OJ; Department of Neurological Surgery, The University of Texas Southwestern, Dallas, TX, United States., El Tecle NE; Department of Neurological Surgery, Saint Louis University Hospital, Saint Louis, MO, United States., Barnett S; Department of Neurological Surgery, The University of Texas Southwestern, Dallas, TX, United States., Gluf W; Department of Neurological Surgery, The University of Texas Southwestern, Dallas, TX, United States.
Jazyk: angličtina
Zdroj: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [J Clin Neurosci] 2019 Apr; Vol. 62, pp. 162-173. Date of Electronic Publication: 2018 Nov 22.
DOI: 10.1016/j.jocn.2018.11.037
Abstrakt: Background: Schwannomas of the hypoglossal nerve are rare and account for a very small percentage of non-vestibular schwannomas.
Objectives: In this systematic review of the literature, we examined the epidemiology, symptomatology, management, and outcomes of patients with hypoglossal schwannomas.
Methods: The electronic database Pubmed was searched for all reports of hypoglossal schwannomas with descriptions of symptoms, management, and outcome characteristics. Data was extracted from each study and compiled in a spreadsheet. Continuous variables were reported as means and medians. Categorical variables were reported as proportions. Additional analysis was not done due to inconsistent reporting of outcomes and small sample sizes.
Results: A total of 59 studies (94 total individual cases) were included. 64% of patients were female with mean age of 44.6 years. The majority were intracranial/extracranial (50%). The most common symptoms were tongue deviation or speech disturbance (38%) and headaches (33%). Hypoglossal nerve dysfunction was present in 80% of patients. Surgical excision was performed in 93%, with a 15% complication rate. Evidence of residual mass after surgery was noted in 29%. Permanent hypoglossal nerve deficits occurred in 67%. Recurrence of tumor burden was reported in 6 studies, with median time to recurrence of 16.5 months.
Conclusion: Current evidence suggests overall favorable outcomes with surgical resection of hypoglossal schwannomas, with a large percentage of patients experiencing mild and usually well-tolerated neurologic deficit. Limitations of this study include the use of retrospective data taken from case reports/series with highly selected patients, selective reporting, and absence of control groups.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE