Role of dopamine D 2 -like receptors and their modulation by adenosine receptor stimulation in the reinstatement of methamphetamine seeking.
Autor: | Larson TA; Department of Psychology and Neuroscience and Center for Neuroscience, University of Colorado Boulder, 2860 Wilderness Place, Boulder, CO, 80301, USA., Winkler MC; Department of Psychology and Neuroscience and Center for Neuroscience, University of Colorado Boulder, 2860 Wilderness Place, Boulder, CO, 80301, USA., Stafford J; Department of Psychology and Neuroscience and Center for Neuroscience, University of Colorado Boulder, 2860 Wilderness Place, Boulder, CO, 80301, USA., Levis SC; Department of Psychology and Neuroscience and Center for Neuroscience, University of Colorado Boulder, 2860 Wilderness Place, Boulder, CO, 80301, USA., O'Neill CE; Department of Psychology and Neuroscience and Center for Neuroscience, University of Colorado Boulder, 2860 Wilderness Place, Boulder, CO, 80301, USA., Bachtell RK; Department of Psychology and Neuroscience and Center for Neuroscience, University of Colorado Boulder, 2860 Wilderness Place, Boulder, CO, 80301, USA. Ryan.Bachtell@Colorado.edu. |
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Jazyk: | angličtina |
Zdroj: | Psychopharmacology [Psychopharmacology (Berl)] 2019 Apr; Vol. 236 (4), pp. 1207-1218. Date of Electronic Publication: 2018 Nov 23. |
DOI: | 10.1007/s00213-018-5126-y |
Abstrakt: | Rationale and Objective: Previous work has demonstrated that dopamine and adenosine receptors are involved in drug-seeking behaviors, yet the pharmacological interactions between these receptors in methamphetamine (MA) seeking are not well characterized. The present studies examined the role of the dopamine D Methods: Adult male Sprague-Dawley rats were trained to lever press for MA in daily 2-h self-administration sessions on a fixed-ratio 1 schedule for 10 consecutive days. After 1 day of abstinence, lever pressing was extinguished in six daily extinction sessions. Treatments were administered systemically prior to a 2-h reinstatement test session. Results: An increase in MA seeking was observed following the administration of the dopamine D Conclusions: These results demonstrate the sufficiency of dopamine D |
Databáze: | MEDLINE |
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