Role of dopamine D 2 -like receptors and their modulation by adenosine receptor stimulation in the reinstatement of methamphetamine seeking.

Autor: Larson TA; Department of Psychology and Neuroscience and Center for Neuroscience, University of Colorado Boulder, 2860 Wilderness Place, Boulder, CO, 80301, USA., Winkler MC; Department of Psychology and Neuroscience and Center for Neuroscience, University of Colorado Boulder, 2860 Wilderness Place, Boulder, CO, 80301, USA., Stafford J; Department of Psychology and Neuroscience and Center for Neuroscience, University of Colorado Boulder, 2860 Wilderness Place, Boulder, CO, 80301, USA., Levis SC; Department of Psychology and Neuroscience and Center for Neuroscience, University of Colorado Boulder, 2860 Wilderness Place, Boulder, CO, 80301, USA., O'Neill CE; Department of Psychology and Neuroscience and Center for Neuroscience, University of Colorado Boulder, 2860 Wilderness Place, Boulder, CO, 80301, USA., Bachtell RK; Department of Psychology and Neuroscience and Center for Neuroscience, University of Colorado Boulder, 2860 Wilderness Place, Boulder, CO, 80301, USA. Ryan.Bachtell@Colorado.edu.
Jazyk: angličtina
Zdroj: Psychopharmacology [Psychopharmacology (Berl)] 2019 Apr; Vol. 236 (4), pp. 1207-1218. Date of Electronic Publication: 2018 Nov 23.
DOI: 10.1007/s00213-018-5126-y
Abstrakt: Rationale and Objective: Previous work has demonstrated that dopamine and adenosine receptors are involved in drug-seeking behaviors, yet the pharmacological interactions between these receptors in methamphetamine (MA) seeking are not well characterized. The present studies examined the role of the dopamine D 2 -like receptors in MA seeking and identified the interactive effects of adenosine receptor stimulation.
Methods: Adult male Sprague-Dawley rats were trained to lever press for MA in daily 2-h self-administration sessions on a fixed-ratio 1 schedule for 10 consecutive days. After 1 day of abstinence, lever pressing was extinguished in six daily extinction sessions. Treatments were administered systemically prior to a 2-h reinstatement test session.
Results: An increase in MA seeking was observed following the administration of the dopamine D 2 -like agonist, quinpirole, or the D 3 receptor agonist, 7-OH-DPAT. Stimulation of D 2 or D 4 receptors was ineffective at inducing MA seeking. Quinpirole-induced MA seeking was inhibited by D 3 receptor antagonism (SB-77011A or PG01037), an adenosine A 1 agonist, CPA, and an adenosine A 2A agonist, CGS 21680. MA seeking induced by a MA priming injection or D 3 receptor stimulation was inhibited by a pretreatment with the adenosine A 1 agonist, CPA, but not the adenosine A 2A agonist, CGS 21680.
Conclusions: These results demonstrate the sufficiency of dopamine D 3 receptors to reinstate MA seeking that is inhibited when combined with adenosine A 1 receptor stimulation.
Databáze: MEDLINE
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