| Autor: |
Izyani Awang AF; Faculty of Pharmacy, International Islamic University Malaysia, Kuantan, Pahang, Malaysia., Ahmed QU; Faculty of Pharmacy, International Islamic University Malaysia, Kuantan, Pahang, Malaysia., Shah SAA; Faculty of Pharmacy, Universiti Teknologi MARA, Selangor D. E., Malaysia.; Atta-ur-Rahman Institute for Natural Products Discovery (AuRIns), Universiti Teknologi MARA, Selangor D. E., Malaysia., Jaffri JM; Faculty of Pharmacy, International Islamic University Malaysia, Kuantan, Pahang, Malaysia., Ghafoor K; Department of Food and Nutrition Sciences, King Saud University, Riyadh, Saudi Arabia., Uddin ABMH; Faculty of Pharmacy, International Islamic University Malaysia, Kuantan, Pahang, Malaysia., Ferdosh S; Faculty of Science, International Islamic University Malaysia, Kuantan, Pahang, Malaysia., Islam Sarker MZ; Faculty of Pharmacy, International Islamic University Malaysia, Kuantan, Pahang, Malaysia. |
| Abstrakt: |
Stereospermum fimbriatum or locally known as "Chicha" is traditionally used for itchy skin, earache, stomachache and postpartum treatments. This study was designed to evaluate the antimicrobial potential of S. fimbriatum's stem bark against 11 pathogens and isolate its bioactive compound. Successive soxhlet extraction was conducted using n -hexane, dichloromethane (DCM) and methanol. Disc diffusion, minimum inhibitory and bactericidal concentration (MIC & MBC) assays were done to examine the antimicrobial activity. Bioassay-guided isolation was conducted on S. fimbriatum's extract. The DCM extract of stem bark (DS) was the most potent extract followed by n- hexane extract of the stem bark (NS). A novel compound was isolated and coded as C1 which demonstrated potent antibacterial effects with the MIC values as low as 3.13 µg/mL to 6.25 µg/mL, against S. epidermidis , MRSA and S. aureus . Thus, S. fimbriatum could be a potential source of antimicrobial agents for the treatment of skin infections, specifically, MRSA. |
