Levothyroxine Replacement Improves Oxidative Status in Primary Hypothyroidism.

Autor: Masullo LF; Research Laboratory in Haemoglobinopathies and Genetics of Haematological Diseases, Federal University of Ceará, Fortaleza, Brazil.; Post-Graduate Program in Pathology, Federal University of Ceará, Fortaleza, Brazil., Magalhães RA; Post-Graduate Program in Pathology, Federal University of Ceará, Fortaleza, Brazil.; Division of Endocrinology and Diabetes, Hospital Universitário Walter Cantídio, Federal University of Ceará, Fortaleza, Brazil., Lemes RPG; Research Laboratory in Haemoglobinopathies and Genetics of Haematological Diseases, Federal University of Ceará, Fortaleza, Brazil.; Post-Graduate Program in Pathology, Federal University of Ceará, Fortaleza, Brazil., de Almeida Filho TP; Research Laboratory in Haemoglobinopathies and Genetics of Haematological Diseases, Federal University of Ceará, Fortaleza, Brazil.; Post-Graduate Program in Pathology, Federal University of Ceará, Fortaleza, Brazil., de Castro MF; Research Laboratory in Haemoglobinopathies and Genetics of Haematological Diseases, Federal University of Ceará, Fortaleza, Brazil., Maia Filho PA; Research Laboratory in Haemoglobinopathies and Genetics of Haematological Diseases, Federal University of Ceará, Fortaleza, Brazil.; Post-Graduate Program in Pathology, Federal University of Ceará, Fortaleza, Brazil., Cunha TOV; Post-Graduate Program in Pathology, Federal University of Ceará, Fortaleza, Brazil., Quidute ARP; Division of Endocrinology and Diabetes, Hospital Universitário Walter Cantídio, Federal University of Ceará, Fortaleza, Brazil.; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil.; Drug Research and Development Center-NPDM/Fortaleza, Fortaleza, Brazil., Fontenele EGP; Division of Endocrinology and Diabetes, Hospital Universitário Walter Cantídio, Federal University of Ceará, Fortaleza, Brazil.; Department of Clinical Medicine, Federal University of Ceará, Fortaleza, Brazil., Sun G; Discipline of Medicine, Faculty of Medicine, Memorial University, St John's, NL, Canada., Martins MRA; Post-Graduate Program in Pathology, Federal University of Ceará, Fortaleza, Brazil.; Division of Endocrinology and Diabetes, Hospital Universitário Walter Cantídio, Federal University of Ceará, Fortaleza, Brazil.; Drug Research and Development Center-NPDM/Fortaleza, Fortaleza, Brazil.; Department of Clinical Medicine, Federal University of Ceará, Fortaleza, Brazil.
Jazyk: angličtina
Zdroj: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2018 Nov 08; Vol. 9, pp. 655. Date of Electronic Publication: 2018 Nov 08 (Print Publication: 2018).
DOI: 10.3389/fendo.2018.00655
Abstrakt: Objective: Although hypothyroidism has been linked to oxidative stress, data regarding the relationship between thyroid hormone levels and oxidative stress is still inconsistent. This study was designed to evaluate the effect of levothyroxine replacement on oxidative stress in women with primary hypothyroidism. Design: A total of 25 female patients with primary hypothyroidism were included. Oxidative stress markers were measured before and after levothyroxine replacement treatment in all patients. Methods: Oxidative stress was evaluated through the measurement of oxidants (thiobarbituric acid reactive substances [TBARS] and nitrite/nitrate levels), and antioxidants (superoxide dismutase and catalase activity). Results: Antioxidant catalase activity (63.77 ± 23.8 vs. 50.12 ±12.75 atv/min; p = 0.03) was significantly increased and the levels of TBARS (3.02 ± 0.86 vs. 3.55 ± 0.87 μM; p = 0.03) were significantly decreased in the state of euthyroidism after levothyroxine replacement compared to the hypothyroidism before levothyroxine treatment. No significant change in neither nitrite/nitrate concentration ( p = 0.18) nor in superoxide dismutase activity ( p = 0.93) after L-T4 adjustment was found. Conclusions: Our data demonstrate that levothyroxine replacement improved oxidative status in patients with primary hypothyroidism, indexed by the significantly decreased levels of malonaldehyde (MDA) and increased catalase (CAT) activity.
Databáze: MEDLINE