Lower Choline Rate in the Left Prefrontal Cortex Is Associated With Higher Amount of Alcohol Use in Alcohol Use Disorder.

Autor:	de Souza RSM; Department of Internal Medicine, Health Sciences Center, Federal University of Espírito Santo, Vitória, Brazil.; Health Sciences Center, University Hospital Cassiano Antônio de Moraes, Federal University of Espírito Santo, Vitória, Brazil.; Department of Radiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; BRAEN - Brazilian Research Group on Brain and Cognitive Engineering, Federal University of Espírito Santo, Vitória, Brazil., Rosa M Jr; Department of Internal Medicine, Health Sciences Center, Federal University of Espírito Santo, Vitória, Brazil., Rodrigues TM; Department of Internal Medicine, Health Sciences Center, Federal University of Espírito Santo, Vitória, Brazil., Escobar TDC; Health Sciences Center, University Hospital Cassiano Antônio de Moraes, Federal University of Espírito Santo, Vitória, Brazil.; BRAEN - Brazilian Research Group on Brain and Cognitive Engineering, Federal University of Espírito Santo, Vitória, Brazil., Gasparetto EL; Department of Radiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Nakamura-Palacios EM; BRAEN - Brazilian Research Group on Brain and Cognitive Engineering, Federal University of Espírito Santo, Vitória, Brazil.; Laboratory of Cognitive Sciences and Neuropsychopharmacology, Graduation Program in Physiological Sciences, Federal University of Espírito Santo, Vitória, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in psychiatry [Front Psychiatry] 2018 Nov 07; Vol. 9, pp. 563. Date of Electronic Publication: 2018 Nov 07 (Print Publication: 2018).
DOI:	10.3389/fpsyt.2018.00563
Abstrakt:	Excessive and long-term alcohol consumption produce metabolic changes, such as of choline, in many brain regions in alcohol use disorder (AUD) and in non-AUD subjects as well. This study examined the association of choline proportion in the prefrontal cortex with pattern of alcohol use in AUD patients. The choline metabolite was acquired through a single voxel Proton Magnetic Resonance Spectroscopy ( 1 H MRS). Between-groups comparison corrected by age showed that the ratio of Choline/Creatine (Cho/Cr) was significantly smaller ( p = 0.005) in the Left Prefrontal (LPF) of AUD patients when compared to paired non-AUD subjects. A multiple regression analysis corrected by age showed that decreasing ratios of Cho/Cr in the LPF was associated with increasing amount of alcohol consumption in drinks per day ( p < 0.01) in AUD patients. Rates of Cho/Cr in the LPF was inversely related to amounts of alcohol consumption possibly indicating the severity of the AUD. Thus, low proportion of Cho/Cr in the LPF could indicate more severe AUD (higher alcohol intake).
Databáze:	MEDLINE
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