Bioavailability and structural study of 20-hydroxyecdysone complexes with cyclodextrins.

Autor: Temirgaziyev BS; International Research and Production Holding 'Phytochemistry', 470000 Karaganda, Kazakhstan; Buketov Karaganda State University, 100028 Karaganda, Kazakhstan., Kučáková K; University of Chemistry and Technology Prague, 166 28 Praha 6, Czech Republic., Baizhigit YA; International Research and Production Holding 'Phytochemistry', 470000 Karaganda, Kazakhstan., Jurášek M; University of Chemistry and Technology Prague, 166 28 Praha 6, Czech Republic., Džubák P; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University and University Hospital in Olomouc, CZ-775 15 Olomouc, Czech Republic., Hajdúch M; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University and University Hospital in Olomouc, CZ-775 15 Olomouc, Czech Republic., Dolenský B; University of Chemistry and Technology Prague, 166 28 Praha 6, Czech Republic. Electronic address: dolenskb@vscht.cz., Drašar PB; University of Chemistry and Technology Prague, 166 28 Praha 6, Czech Republic., Tuleuov BI; International Research and Production Holding 'Phytochemistry', 470000 Karaganda, Kazakhstan., Adekenov SM; International Research and Production Holding 'Phytochemistry', 470000 Karaganda, Kazakhstan. Electronic address: arglabin@phyto.kz.
Jazyk: angličtina
Zdroj: Steroids [Steroids] 2019 Jul; Vol. 147, pp. 37-41. Date of Electronic Publication: 2018 Nov 17.
DOI: 10.1016/j.steroids.2018.11.007
Abstrakt: 20-Hydroxyecdysterone - (2β,3β,5β,22R)-2,3,14,20,22,25-hexahydroxycholest-7-en-6-one was isolated in satisfactory yield using ethanol extraction from the aerial part of Silene wolgensis (Hornem.) Otth; sometimes Silene wolgensis (Willd.) Bess. ex Spreng. The complexation of the phytoecdysteroid with β-cyclodextrin was studied by NMR spectroscopy. By studying the changes in chemical shifts of protons of substrates and receptors it was found that ecdysterone interacts with cyclodextrins to form supramolecular inclusion complexes of stoichiometric composition of 1:1 or 1:2. Ecdysterone-β-cyclodextrin complexes exhibit 100 times higher solubility in water than the parent compound.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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