Genome sequence of the opportunistic human pathogen Magnusiomyces capitatus.

Autor: Brejová B; Faculty of Mathematics, Physics, and Informatics, Comenius University in Bratislava, Bratislava, Slovakia. brejova@dcs.fmph.uniba.sk., Lichancová H; Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia., Brázdovič F; Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia., Hegedűsová E; Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia.; Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, České Budějovice, Czech Republic., Forgáčová Jakúbková M; Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia., Hodorová V; Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia., Džugasová V; Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia., Baláž A; Faculty of Mathematics, Physics, and Informatics, Comenius University in Bratislava, Bratislava, Slovakia., Zeiselová L; Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia., Cillingová A; Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia., Neboháčová M; Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia., Raclavský V; Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic., Tomáška Ľ; Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia., Lang BF; Robert Cedergren Centre for Bioinformatics and Genomics, Université de Montréal, Montréal, QC, Canada., Vinař T; Faculty of Mathematics, Physics, and Informatics, Comenius University in Bratislava, Bratislava, Slovakia., Nosek J; Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia. jozef.nosek@uniba.sk.
Jazyk: angličtina
Zdroj: Current genetics [Curr Genet] 2019 Apr; Vol. 65 (2), pp. 539-560. Date of Electronic Publication: 2018 Nov 19.
DOI: 10.1007/s00294-018-0904-y
Abstrakt: The yeast Magnusiomyces capitatus is an opportunistic human pathogen causing rare yet severe infections, especially in patients with hematological malignancies. Here, we report the 20.2 megabase genome sequence of an environmental strain of this species as well as the genome sequences of eight additional isolates from human and animal sources providing an insight into intraspecies variation. The distribution of single-nucleotide variants is indicative of genetic recombination events, supporting evidence for sexual reproduction in this heterothallic yeast. Using RNAseq-aided annotation, we identified genes for 6518 proteins including several expanded families such as kexin proteases and Hsp70 molecular chaperones. Several of these families are potentially associated with the ability of M. capitatus to infect and colonize humans. For the purpose of comparative analysis, we also determined the genome sequence of a closely related yeast, Magnusiomyces ingens. The genome sequences of M. capitatus and M. ingens exhibit many distinct features and represent a basis for further comparative and functional studies.
Databáze: MEDLINE
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