Seizure frequency and risk of cognitive impairment in people living with epilepsy in a sub-urban community in South Eastern Nigeria.

Autor: Arinzechi EO; Department of Medicine, Neurology Unit, Nnamdi Azikiwe University Teaching, Nnewi, Nigeria., Ogunrin OA; Department of Medicine, Neurology Unit, University of Benin Teaching Hospital, Benin City, Nigeria., Nwosu CM; Department of Medicine, Neurology Unit, Nnamdi Azikiwe University Teaching, Nnewi, Nigeria., Nwani PO; Department of Medicine, Neurology Unit, Nnamdi Azikiwe University Teaching, Nnewi, Nigeria., Enwereji KO; Department of Medicine, Neurology Unit, Nnamdi Azikiwe University Teaching, Nnewi, Nigeria., Asomugha LA; Department of Medicine, Neurology Unit, Nnamdi Azikiwe University Teaching, Nnewi, Nigeria., Dimkpa U; Department of Human Physiology, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Nnewi, Nigeria. Electronic address: positivedoings@yahoo.com.
Jazyk: angličtina
Zdroj: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [J Clin Neurosci] 2019 Jan; Vol. 59, pp. 98-105. Date of Electronic Publication: 2018 Nov 13.
DOI: 10.1016/j.jocn.2018.10.120
Abstrakt: This study is aimed at assessing the impact of seizure frequency on the cognitive performance of epileptic adult patients in a rural community in South Eastern Nigeria. A total of 51 patients with epilepsy (33 males and 18 females) with a mean age of 30.7 ± 12.1 years and 51 age and sex matched controls participated in this study. The cognitive performances of the people with epilepsy and controls were assessed using the Community Screening Interview for Dementia (CSID) and the computerized cognitive assessment test battery, the FePsy. The control group performed better in almost all the neurocognitive tests compared with the low seizure frequency (LSF) and high seizure frequency (HSF) groups. Analysis of covariance revealed that patients with LSF performed better (p = 0.04) in visual reaction time - dominant hand (VRT-D) compared with the HSF group. There was lack of significant differences in mean total CSID scores and mean sub-total scores for language, memory, orientation, attention, constructional praxis, auditory reaction time-dominant hand and non-dominant hand, VRT - non-dominant hand and figure recognition. HSF patients indicated significantly greater prevalence (80% vs. 20%; p = 0.020) and risk (OR, 8.0; 95% CI, 1.8-33.8)) of memory impairment, but not in the other neurocognitive domains compared with the LSF group. In conclusion, the present study indicated that adults with epilepsy performed poorly in a wide range of neurocognitive variables compared with the controls. However, no significant adverse effects of high seizure frequency were observed on almost all the neurocognitive variables.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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