Vaccinating against monkeypox in the Democratic Republic of the Congo.

Autor: Petersen BW; U.S. Centers for Disease Control and Prevention, Atlanta, USA. Electronic address: bpetersen@cdc.gov., Kabamba J; U.S. Centers for Disease Control and Prevention, Kinshasa, Democratic Republic of the Congo., McCollum AM; U.S. Centers for Disease Control and Prevention, Atlanta, USA., Lushima RS; Hemorrhagic Fever and Monkeypox Program, Ministry of Health, Kinshasa, Democratic Republic of the Congo., Wemakoy EO; Kinshasa School of Public Health, Kinshasa, Democratic Republic of the Congo., Muyembe Tamfum JJ; National Institute for Biomedical Research, Kinshasa, Democratic Republic of the Congo., Nguete B; Kinshasa School of Public Health, Kinshasa, Democratic Republic of the Congo., Hughes CM; U.S. Centers for Disease Control and Prevention, Atlanta, USA., Monroe BP; U.S. Centers for Disease Control and Prevention, Atlanta, USA., Reynolds MG; U.S. Centers for Disease Control and Prevention, Atlanta, USA.
Jazyk: angličtina
Zdroj: Antiviral research [Antiviral Res] 2019 Feb; Vol. 162, pp. 171-177. Date of Electronic Publication: 2018 Nov 14.
DOI: 10.1016/j.antiviral.2018.11.004
Abstrakt: Healthcare-associated transmission of monkeypox has been observed on multiple occasions in areas where the disease is endemic. Data collected by the US Centers for Disease Control and Prevention (CDC) from an ongoing CDC-supported program of enhanced surveillance in the Tshuapa Province of the Democratic Republic of the Congo, where the annual incidence of human monkeypox is estimated to be 3.5-5/10,000, suggests that there is approximately one healthcare worker infection for every 100 confirmed monkeypox cases. Herein, we describe a study that commenced in February 2017, the intent of which is to evaluate the effectiveness, immunogenicity, and safety of a third-generation smallpox vaccine, IMVAMUNE ® , in healthcare personnel at risk of monkeypox virus (MPXV) infection. We describe procedures for documenting exposures to monkeypox virus infection in study participants, and outline lessons learned that may be of relevance for studies of other investigational medical countermeasures in hard to reach, under-resourced populations.
(Copyright © 2018. Published by Elsevier B.V.)
Databáze: MEDLINE
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