Harnessing stem cells and biomaterials to promote neural repair.

Autor: Bruggeman KF; Laboratory of Advanced Biomaterials, Research School of Engineering, The Australian National University, Canberra, ACT, Australia., Moriarty N; Pharmacology and Therapeutics and Galway Neuroscience Centre, National University of Ireland Galway, Galway, Ireland., Dowd E; Pharmacology and Therapeutics and Galway Neuroscience Centre, National University of Ireland Galway, Galway, Ireland., Nisbet DR; Laboratory of Advanced Biomaterials, Research School of Engineering, The Australian National University, Canberra, ACT, Australia., Parish CL; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Jazyk: angličtina
Zdroj: British journal of pharmacology [Br J Pharmacol] 2019 Feb; Vol. 176 (3), pp. 355-368. Date of Electronic Publication: 2018 Dec 21.
DOI: 10.1111/bph.14545
Abstrakt: With the limited capacity for self-repair in the adult CNS, efforts to stimulate quiescent stem cell populations within discrete brain regions, as well as harness the potential of stem cell transplants, offer significant hope for neural repair. These new cells are capable of providing trophic cues to support residual host populations and/or replace those cells lost to the primary insult. However, issues with low-level adult neurogenesis, cell survival, directed differentiation and inadequate reinnervation of host tissue have impeded the full potential of these therapeutic approaches and their clinical advancement. Biomaterials offer novel approaches to stimulate endogenous neurogenesis, as well as for the delivery and support of neural progenitor transplants, providing a tissue-appropriate physical and trophic milieu for the newly integrating cells. In this review, we will discuss the various approaches by which bioengineered scaffolds may improve stem cell-based therapies for repair of the CNS.
(© 2018 The British Pharmacological Society.)
Databáze: MEDLINE
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