Cell Attachment on Inside-Outside Surface and Cell Encapsulation in Wall of Microscopic Tubular Scaffolds for Vascular Tissue-Like Formation.

Autor: Duong VT, Dang TT, Lee Y, Nguyen CT, Phan HL, Shin D, Lee Y, Park H, Lee H, Son H, Jang H, Oh S, Back SH, Hwang C, Koo AK
Jazyk: angličtina
Zdroj: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference [Annu Int Conf IEEE Eng Med Biol Soc] 2018 Jul; Vol. 2018, pp. 4198-4201.
DOI: 10.1109/EMBC.2018.8513248
Abstrakt: By using the microfluidic spinning technology we generated tiny hydrogel tubular scaffolds. Fibroblast (NIH/3T3) cell cultures were performed for seventeen days to demonstrate the potential of cell attachment on surfaces and encapsulation in the wall of he microscopic scaffolds for blood vessel-like structure forming. Over theculture period, the NIH/3T3 confluence reached around 80\%, and 100\% on the inside and outside scaffolds' surface respectively while cells proliferated and coalesced in cell group in the hydrogel wall. These results could further be applied to endothelial co-culturing for forming engineered blood vessel.
Databáze: MEDLINE