Maternal Gestational Immune Response and Autism Spectrum Disorder Phenotypes at 7 Years of Age in the Seychelles Child Development Study.

Autor: Irwin JL; Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, 265 Crittenden Blvd, CU 420644, 601 Elmwood Avenue, Rochester, NY, 14642, USA., Yeates AJ; Nutrition Innovation Centre for Food and Health (NICHE), Ulster University, Cromore Road, Coleraine, Co. Londonderry, BT52 1SA, UK., Mulhern MS; Nutrition Innovation Centre for Food and Health (NICHE), Ulster University, Cromore Road, Coleraine, Co. Londonderry, BT52 1SA, UK., McSorley EM; Nutrition Innovation Centre for Food and Health (NICHE), Ulster University, Cromore Road, Coleraine, Co. Londonderry, BT52 1SA, UK., Strain JJ; Nutrition Innovation Centre for Food and Health (NICHE), Ulster University, Cromore Road, Coleraine, Co. Londonderry, BT52 1SA, UK., Watson GE; Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, 265 Crittenden Blvd, CU 420644, 601 Elmwood Avenue, Rochester, NY, 14642, USA., Grzesik K; Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, 265 Crittenden Blvd, CU 420644, 601 Elmwood Avenue, Rochester, NY, 14642, USA., Thurston SW; Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, 265 Crittenden Blvd, CU 420644, 601 Elmwood Avenue, Rochester, NY, 14642, USA., Love TM; Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, 265 Crittenden Blvd, CU 420644, 601 Elmwood Avenue, Rochester, NY, 14642, USA., Smith TH; Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, 265 Crittenden Blvd, CU 420644, 601 Elmwood Avenue, Rochester, NY, 14642, USA., Mruzek DW; Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, 265 Crittenden Blvd, CU 420644, 601 Elmwood Avenue, Rochester, NY, 14642, USA., Shamlaye CF; Ministry of Health, Box 52, Mahé, Republic of Seychelles., Monthy C; Ministry of Education & Human Resource Development, Box 48, Mahé, Republic of Seychelles., Myers GJ; Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, 265 Crittenden Blvd, CU 420644, 601 Elmwood Avenue, Rochester, NY, 14642, USA., Davidson PW; Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, 265 Crittenden Blvd, CU 420644, 601 Elmwood Avenue, Rochester, NY, 14642, USA., van Wijngaarden E; Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, 265 Crittenden Blvd, CU 420644, 601 Elmwood Avenue, Rochester, NY, 14642, USA. edwin_van_wijngaarden@urmc.rochester.edu.
Jazyk: angličtina
Zdroj: Molecular neurobiology [Mol Neurobiol] 2019 Jul; Vol. 56 (7), pp. 5000-5008. Date of Electronic Publication: 2018 Nov 14.
DOI: 10.1007/s12035-018-1424-y
Abstrakt: Findings from observational and experimental studies suggest that maternal inflammation during pregnancy is associated with autism spectrum disorder (ASD). We report the first study in humans to examine this association in a large prospective birth cohort. We studied 788 mother-child pairs from the Seychelles Child Development Study Nutrition Cohort 2. Thirteen inflammatory markers were measured in mothers' serum at 28 weeks' gestation, along with the sum of T-helper 1 (Th1) and 2 (Th2) cytokines. The Social Communication Questionnaire (SCQ) and Social Responsiveness Scale (SRS) were administered at age 7 years to obtain information on ASD phenotype. We evaluated associations between maternal inflammatory markers and ASD phenotype using multivariable linear regression. For the SCQ, increased MCP-1 (a chemokine that is upregulated in response to pro-inflammatory cytokines) was associated with fewer ASD symptoms (B = - 0.40; 95% CI = - 0.72, - 0.09). Increased IL-4 (a cytokine that is typically associated with an enhanced anti-inflammatory response) was associated with more ASD symptoms (B = 2.10; 95% CI = 0.78, 3.43). For the SRS, higher concentrations of the anti-inflammatory cytokine IL-10 were associated with fewer ASD symptoms (B = - 0.18; 95% CI = - 0.35, - 0.01), but only after removal of outliers. No associations were observed for other markers. These findings suggest that a shift in the maternal immune balance during pregnancy may be associated with ASD symptomatology. While the use of well-established measures that capture ASD phenotypic variability is a strength of the study, measurement of peripheral immune markers only once during gestation is a limitation. Our results should be confirmed using maternal immune markers measured throughout gestation.
Databáze: MEDLINE
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