| Autor: |
Brito AF; School of Physical Education, University of Pernambuco, Recife, Brazil.; Post-Graduation Program in Physical Education UPE/UFPB, Recife, Brazil., Silva AS; Post-Graduation Program in Physical Education UPE/UFPB, Recife, Brazil.; Physical Education Department, Health Sciences Center, Federal University of Paraiba, João Pessoa, Brazil., de Souza AA; Federal University of Tocantins, Licentiate in Physical Education, Tocantinópolis, Brazil., Ferreira PB; Postgraduate Program in Natural and Synthetic Products Bioactive, Health Sciences Center, Federal University of Paraiba, João Pessoa, Brazil., de Souza ILL; Postgraduate Program in Natural and Synthetic Products Bioactive, Health Sciences Center, Federal University of Paraiba, João Pessoa, Brazil., Araujo LCDC; Department of Biophysics and Physiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Félix GDS; Post-Graduation Program in Physical Education UPE/UFPB, Recife, Brazil., Sampaio RS; Postgraduate Program in Natural and Synthetic Products Bioactive, Health Sciences Center, Federal University of Paraiba, João Pessoa, Brazil., Silva MDCC; Postgraduate Program in Natural and Synthetic Products Bioactive, Health Sciences Center, Federal University of Paraiba, João Pessoa, Brazil., Tavares RL; Laboratory of Studies of Physical Training Applied to the Performance and the Health, Health Sciences Center, Federal University of Paraiba, João Pessoa, Brazil., Pereira RA; Post-Graduation Program in Physical Education UPE/UFPB, Recife, Brazil., Miranda Neto M; Laboratory of Studies of Physical Training Applied to the Performance and the Health, Health Sciences Center, Federal University of Paraiba, João Pessoa, Brazil., da Silva BA; Postgraduate Program in Natural and Synthetic Products Bioactive, Health Sciences Center, Federal University of Paraiba, João Pessoa, Brazil.; Pharmaceutical Sciences Department, Health Sciences Center, Federal University of Paraiba, João Pessoa, Brazil. |
| Abstrakt: |
Studies have shown that supplementation with Spirulina platensis improves vascular reactivity. However, it is unclear whether in association with strength training this effect can be enhanced. Thus, this study aimed to determine the effects of strength training and S. platensis on the reactivity of the aorta from Wistar rat and the possible mechanisms involved. The animals were supplemented with S. platensis and divided into sedentary (SG, SG50, SG150, and SG500) and trained groups (TG, TG50, TG150, and TG500). Nitrite, malondialdehyde (MDA) and antioxidant activity were determined by biochemical assays. To evaluate vascular response, cumulative concentration-response curves to phenylephrine (PHE) and acetylcholine (ACh) were constructed. L-NAME was used to assess the participation of nitric oxide (NO). It was observed that the PHE contractile potency was reduced in TG50, TG150, and TG500 groups compared to SG50, SG150, and SG500 groups, respectively. However, the presence of L-NAME increased the contractile response in all groups. Strength training potentiated the increase in relaxing activity induced by S. platensis , where the pCE 50 values of ACh increased in TG150 and TG500. These responses were accompanied by increased nitrite production, MDA reduction and increased antioxidant activity in the aorta of both TG150 and TG500 groups. Thus, the present study demonstrated that combined with strength training, S. platensis potentiates vascular improvement through the participation of NO and reduction of oxidative stress. |
