Dual Functionalization of Nanoparticles for Generating Corona-Free and Noncytotoxic Silica Nanoparticles.

Autor: Affonso de Oliveira JF; Laboratório Nacional de Nanotecnologia (LNNano) and Laboratório Nacional de Luz Síncrotron (LNLS)/Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) , CEP 13083-970 , Caixa Postal, 6192 Campinas , São Paulo , Brazil.; Instituto de Química (IQ), Universidade Estadual de Campinas (UNICAMP) , CEP 13083-970 , Caixa Postal, 6154 Campinas , São Paulo , Brazil.; Department of Chemistry , University of Massachusetts Amherst , 710 North Pleasant Street , Amherst , Massachusetts 01003 , United States., Scheffer FR; Laboratório Nacional de Nanotecnologia (LNNano) and Laboratório Nacional de Luz Síncrotron (LNLS)/Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) , CEP 13083-970 , Caixa Postal, 6192 Campinas , São Paulo , Brazil.; Instituto de Química (IQ), Universidade Estadual de Campinas (UNICAMP) , CEP 13083-970 , Caixa Postal, 6154 Campinas , São Paulo , Brazil., Landis RF; Department of Chemistry , University of Massachusetts Amherst , 710 North Pleasant Street , Amherst , Massachusetts 01003 , United States., Teixeira Neto É; Laboratório Nacional de Nanotecnologia (LNNano) and Laboratório Nacional de Luz Síncrotron (LNLS)/Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) , CEP 13083-970 , Caixa Postal, 6192 Campinas , São Paulo , Brazil., Rotello VM; Department of Chemistry , University of Massachusetts Amherst , 710 North Pleasant Street , Amherst , Massachusetts 01003 , United States., Cardoso MB; Laboratório Nacional de Nanotecnologia (LNNano) and Laboratório Nacional de Luz Síncrotron (LNLS)/Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) , CEP 13083-970 , Caixa Postal, 6192 Campinas , São Paulo , Brazil.; Instituto de Química (IQ), Universidade Estadual de Campinas (UNICAMP) , CEP 13083-970 , Caixa Postal, 6154 Campinas , São Paulo , Brazil.
Jazyk: angličtina
Zdroj: ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2018 Dec 12; Vol. 10 (49), pp. 41917-41923. Date of Electronic Publication: 2018 Dec 03.
DOI: 10.1021/acsami.8b12351
Abstrakt: Protein coronas form on the surfaces of nanomaterials in biological fluids. This layer of proteins affects the properties of nanomaterials, altering their behavior and masking engineered functionality. The use of nonfouling moieties reduces or prevents corona formation; however, these ligands typically complicate functionalization. We present here a surface modification strategy for silica nanoparticles using specific molar ratios of zwitterionic and amine moieties. Through proper balance of ligands, we were able to generate particles that featured reactive "handles", while retaining nonfouling properties, high hemocompatibility, and low cytotoxicity.
Databáze: MEDLINE
Externí odkaz: