A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults.

Autor: Hansen LBS; Department of Bio and Health Informatics, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark., Roager HM; National Food Institute, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark.; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, DK-1958, Frederiksberg, Denmark., Søndertoft NB; The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, DK-2200, Copenhagen, Denmark., Gøbel RJ; The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, DK-2200, Copenhagen, Denmark., Kristensen M; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, DK-1958, Frederiksberg, Denmark., Vallès-Colomer M; Department of Microbiology and Immunology, KU Leuven-University of Leuven, Rega Institute, 3000, Leuven, Belgium.; VIB, Center for Microbiology, 3000, Leuven, Belgium., Vieira-Silva S; Department of Microbiology and Immunology, KU Leuven-University of Leuven, Rega Institute, 3000, Leuven, Belgium.; VIB, Center for Microbiology, 3000, Leuven, Belgium., Ibrügger S; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, DK-1958, Frederiksberg, Denmark., Lind MV; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, DK-1958, Frederiksberg, Denmark., Mærkedahl RB; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, DK-1958, Frederiksberg, Denmark.; Department of Veterinary Disease Biology, Faculty of Science, University of Copenhagen, DK-1958, Frederiksberg, Denmark., Bahl MI; National Food Institute, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark., Madsen ML; The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, DK-2200, Copenhagen, Denmark., Havelund J; Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230, Odense, Denmark., Falony G; Department of Microbiology and Immunology, KU Leuven-University of Leuven, Rega Institute, 3000, Leuven, Belgium.; VIB, Center for Microbiology, 3000, Leuven, Belgium., Tetens I; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, DK-1958, Frederiksberg, Denmark., Nielsen T; The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, DK-2200, Copenhagen, Denmark., Allin KH; The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, DK-2200, Copenhagen, Denmark., Frandsen HL; National Food Institute, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark., Hartmann B; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, DK-2200, Denmark., Holst JJ; The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, DK-2200, Copenhagen, Denmark., Sparholt MH; Department of Radiology, Bispebjerg Hospital, Copenhagen, DK-2400, Denmark., Holck J; Department of Chemical and Biochemical Engineering, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark., Blennow A; Department of Plant and Environmental Sciences, University of Copenhagen, DK-1958, Frederiksberg, Denmark., Moll JM; Department of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark., Meyer AS; Department of Chemical and Biochemical Engineering, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark., Hoppe C; National Food Institute, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark., Poulsen JH; Department of Clinical Biochemistry, Copenhagen University Hospital Hvidovre, DK-2650, Hvidovre, Denmark., Carvalho V; National Food Institute, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark., Sagnelli D; Department of Plant and Environmental Sciences, University of Copenhagen, DK-1958, Frederiksberg, Denmark., Dalgaard MD; Department of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark., Christensen AF; Department of Radiology, Bispebjerg Hospital, Copenhagen, DK-2400, Denmark., Lydolph MC; Department of Autoimmunology & Biomarkers, Statens Serum Institut, DK-2300, Copenhagen, Denmark., Ross AB; Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96, Gothenburg, Sweden., Villas-Bôas S; School of Biological Sciences, The University of Auckland, 1010, Auckland, New Zealand., Brix S; Department of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark., Sicheritz-Pontén T; Department of Bio and Health Informatics, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark., Buschard K; Bartholin Institute, Rigshospitalet, DK-2200, Copenhagen, Denmark., Linneberg A; Research Centre for Prevention and Health, The Capital Region of Denmark, DK-2000, Frederiksberg, Denmark., Rumessen JJ; Research Unit and Department of Gastroenterology, Herlev and Gentofte Hospital, the Capital Region of Denmark, 2730, Herlev, Denmark., Ekstrøm CT; Biostatistics, Department of Public Health, University of Copenhagen, DK-1014, Copenhagen, Denmark., Ritz C; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, DK-1958, Frederiksberg, Denmark., Kristiansen K; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, DK-2100, Copenhagen, Denmark., Nielsen HB; Clinical-Microbiomics A/S, DK-2200, Copenhagen, Denmark., Vestergaard H; The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, DK-2200, Copenhagen, Denmark., Færgeman NJ; Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230, Odense, Denmark., Raes J; Department of Microbiology and Immunology, KU Leuven-University of Leuven, Rega Institute, 3000, Leuven, Belgium.; VIB, Center for Microbiology, 3000, Leuven, Belgium., Frøkiær H; Department of Veterinary Disease Biology, Faculty of Science, University of Copenhagen, DK-1958, Frederiksberg, Denmark., Hansen T; The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, DK-2200, Copenhagen, Denmark., Lauritzen L; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, DK-1958, Frederiksberg, Denmark., Gupta R; Department of Bio and Health Informatics, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark. ramneek@bioinformatics.dtu.dk., Licht TR; National Food Institute, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark. trli@food.dtu.dk., Pedersen O; The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, DK-2200, Copenhagen, Denmark. oluf@sund.ku.dk.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2018 Nov 13; Vol. 9 (1), pp. 4630. Date of Electronic Publication: 2018 Nov 13.
DOI: 10.1038/s41467-018-07019-x
Abstrakt: Adherence to a low-gluten diet has become increasingly common in parts of the general population. However, the effects of reducing gluten-rich food items including wheat, barley and rye cereals in healthy adults are unclear. Here, we undertook a randomised, controlled, cross-over trial involving 60 middle-aged Danish adults without known disorders with two 8-week interventions comparing a low-gluten diet (2 g gluten per day) and a high-gluten diet (18 g gluten per day), separated by a washout period of at least six weeks with habitual diet (12 g gluten per day). We find that, in comparison with a high-gluten diet, a low-gluten diet induces moderate changes in the intestinal microbiome, reduces fasting and postprandial hydrogen exhalation, and leads to improvements in self-reported bloating. These observations suggest that most of the effects of a low-gluten diet in non-coeliac adults may be driven by qualitative changes in dietary fibres.
Databáze: MEDLINE
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