Cannabinoid dependence induces sustained changes in GABA release in the globus pallidus without affecting dopamine release in the dorsal striatum: A dual microdialysis probe study.

Autor: Moreno M; Department of Neuroscience, The Scripps Research Institute, San Diego, CA, USA.; Departamento de Psicologia y CIAIMBITAL, CeiA3, Universidad de Almería, Almería, Spain., Decara J; Laboratorio de Neuropsicofarmacología, Unidad de Gestión Clínica de Salud Mental, Instituto de Investigación Biomédica de Málaga, Hospital Regional Universitario de Málaga, Málaga, Spain., Pavon FJ; Laboratorio de Neuropsicofarmacología, Unidad de Gestión Clínica de Salud Mental, Instituto de Investigación Biomédica de Málaga, Hospital Regional Universitario de Málaga, Málaga, Spain., Stouffer DG; Department of Neuroscience, The Scripps Research Institute, San Diego, CA, USA., Edwards S; Department of Neuroscience, The Scripps Research Institute, San Diego, CA, USA., Serrano A; Laboratorio de Neuropsicofarmacología, Unidad de Gestión Clínica de Salud Mental, Instituto de Investigación Biomédica de Málaga, Hospital Regional Universitario de Málaga, Málaga, Spain., Suárez J; Laboratorio de Neuropsicofarmacología, Unidad de Gestión Clínica de Salud Mental, Instituto de Investigación Biomédica de Málaga, Hospital Regional Universitario de Málaga, Málaga, Spain., Parsons LH; Department of Neuroscience, The Scripps Research Institute, San Diego, CA, USA., Rodríguez de Fonseca F; Laboratorio de Neuropsicofarmacología, Unidad de Gestión Clínica de Salud Mental, Instituto de Investigación Biomédica de Málaga, Hospital Regional Universitario de Málaga, Málaga, Spain.
Jazyk: angličtina
Zdroj: Addiction biology [Addict Biol] 2018 Nov; Vol. 23 (6), pp. 1251-1261. Date of Electronic Publication: 2018 Nov 13.
DOI: 10.1111/adb.12694
Abstrakt: A dual probe microdialysis study was designed to characterize GABA and dopamine (DA) release in the basal ganglia of cannabinoid-dependent Wistar rats. Whereas chronic administration of the cannabinoid receptor agonist WIN55,212 (WIN) resulted in increased basal GABA release, the D2 agonist receptor-mediated control of GABA and DA release elicited by quinpirole was similar in both cannabinoid-dependent and non dependent animals. However, quinpirole did induce a greater number of more stereotypies in cannabinoid-dependent animals, indicating a dysregulated behavioral response.
(© 2018 Society for the Study of Addiction.)
Databáze: MEDLINE
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