Correspondence between bone mineral density and intervertebral disc degeneration across age and sex.

Autor: Kaiser J; Department of Mechanical Engineering, Boston University, 110 Cummington Street, Boston, MA, 02215, USA. jmkaiser@bu.edu., Allaire B; Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA, USA., Fein PM; Department of Mechanical Engineering, Boston University, 110 Cummington Street, Boston, MA, 02215, USA., Lu D; Department of Biostatistics, Boston University, Boston, MA, USA., Jarraya M; Boston University School of Medicine, Boston, MA, USA.; Department of Radiology, Mercy Catholic Medical Center, Darby, PA, USA., Guermazi A; Boston University School of Medicine, Boston, MA, USA., Demissie S; Department of Biostatistics, Boston University, Boston, MA, USA., Samelson EJ; Institute for Aging Research, Hebrew Senior Life, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Bouxsein ML; Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Dept of Orthopedic Surgery, Harvard Medical School, Boston, MA, USA., Morgan EF; Department of Mechanical Engineering, Boston University, 110 Cummington Street, Boston, MA, 02215, USA.
Jazyk: angličtina
Zdroj: Archives of osteoporosis [Arch Osteoporos] 2018 Nov 12; Vol. 13 (1), pp. 123. Date of Electronic Publication: 2018 Nov 12.
DOI: 10.1007/s11657-018-0538-1
Abstrakt: The distribution of bone tissue within the vertebra can modulate vertebral strength independently of average density and may change with age and disc degeneration. Our results show that the age-associated decrease in bone density is spatially non-uniform and associated with disc health, suggesting a mechanistic interplay between disc and vertebra.
Purpose: While the decline of bone mineral density (BMD) in the aging spine is well established, the extent to which age influences BMD distribution within the vertebra is less clear. Measures of regional BMD (rBMD) may improve predictions of vertebral strength and suggest how vertebrae might adapt with intervertebral disc degeneration. Thus, we aimed to assess how rBMD values were associated with age, sex, and disc height loss (DHL).
Methods: We measured rBMD in the L3 vertebra of 377 participants from the Framingham Heart Study (41-83 years, 181 M/196 F). Integral (Int.BMD) and trabecular BMD (Tb.BMD) were measured from QCT images. rBMD ratios (anterior/posterior, superior/mid-transverse, inferior/mid-transverse, and central/outer) were calculated from the centrum. A radiologist assigned a DHL severity score to adjacent intervertebral discs (L2-L3 and L3-L4).
Results: Int.BMD and Tb.BMD were both associated with age, though the decrease across age was greater in women (Int.BMD, - 2.6 mg/cm 3 per year; Tb.BMD, - 2.6 mg/cm 3 per year) than men (Int.BMD, - 0.5 mg/cm 3 per year; Tb.BMD, - 1.2 mg/cm 3 per year). The central/outer (- 0.027/decade) and superior/mid-transverse (- 0.018/decade) rBMD ratios were negatively associated with age, with similar trends in men and women. Higher Int.BMD or Tb.BMD was associated with increased odds of DHL after adjusting for age and sex. Low central/outer ratio and high anterior/poster and superior/mid-transverse ratios were also associated with increased odds of DHL.
Conclusions: Our results indicate that the distribution of bone within the L3 vertebra is different across age, but not between sexes, and is associated with disc degeneration.
Databáze: MEDLINE
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